Asthma and subjective sleep disordered breathing in a large cohort of urban adolescents.
Asthma and subjective sleep disordered breathing in a large cohort of urban adolescents.
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大量城市青少年的哮喘和主观睡眠呼吸障碍。
DOI：
10.1080/02770903.2016.1188942
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Bruzzese,Jean-Marie
中科院分区：
文献类型：
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作者：
Zandieh,StephanieO;Cespedes,Amarilis;Ciarleglio,Adam;Bourgeois,Wallace;Rapoport,DavidM;Bruzzese,Jean-Marie
睡眠呼吸障碍（SDB）尚未在社区环境中对城市青少年哮喘患者进行充分研究。SDB症状和哮喘严重程度之间的关系也没有研究。我们描述了自我报告的提示SDB的症状，并调查了SDB症状、可能的哮喘和哮喘严重程度之间的关系。方法对来自21所市中心高中的9,565名青少年进行了哮喘干预研究。学生们使用2007年NHANES中的问题报告了提示SDB的症状，如果他们曾经被诊断患有哮喘，以及哮喘症状。使用广义线性混合模型与logit链接与学校作为一个随机截距，并调整年龄，性别和种族/民族，我们研究了SDB症状，人口统计学特征，可能的哮喘，哮喘severity.Results12%的SDB症状。老年人和双种族参与者（与白人相比）有更高的提示SDB的症状几率（p<.001）。与那些没有可能的哮喘的青少年相比，有可能的哮喘的青少年报告SDB症状的几率高2.63（p<0.001）。在可能患有哮喘的患者中，报告SDB症状的几率随着哮喘严重程度的增加而增加。当探索白天的严重程度和严重程度，由于夜间觉醒分别，结果是相似的。所有的结果仍然显着控制年龄，性别和ethnication.ConclusionsIn一个大型的城市社区队列的主要少数民族青少年，自我报告的SDB症状与可能的哮喘和哮喘严重程度增加。这项研究强调了SDB作为哮喘可改变的合并症的重要性。
ObjectiveSleep disordered breathing (SDB) has not been well studied in urban adolescents with asthma in community settings. Nor has the association of SDB symptoms and asthma severity been studied. We characterized self-reported symptoms suggesting SDB and investigated the association of SDB symptoms, probable asthma, and asthma severity.Methods9,565 adolescents from 21 inner-city high schools were screened for an asthma intervention study. Students reported on symptoms suggesting SDB using questions from the 2007 NHANES, if they were ever diagnosed with asthma, and on asthma symptoms. Using generalized linear mixed models with logit link with school as a random intercept and adjusting for age, gender, and race/ethnicity, we examined associations of SDB symptoms, and demographic characteristics, probable asthma, and asthma severity.Results12% reported SDB symptoms. Older and bi-racial participants (compared to Caucasian) had higher odds of symptoms suggesting SDB (p<.001). Compared to those without probable asthma, adolescents with probable asthma had 2.63 greater odds of reporting SDB symptoms (p<.001). Among those with probable asthma, the odds of reporting SDB symptoms increased with asthma severity. When exploring daytime severity and severity due to night wakening separately, results were similar. All results remained significant when controlling for age, gender, and ethnicity.ConclusionsIn a large urban community cohort of predominately ethnic minority adolescents, self-reported SDB symptoms were associated with probable asthma and increased asthma severity. This study highlights the importance of SDB as a modifiable co-morbidity of asthma.