Mini Nutritional Assessment in patients with Parkinson's disease: correlation between worsening of the malnutrition and increasing number of disease-years
Mini Nutritional Assessment in patients with Parkinson's disease: correlation between worsening of the malnutrition and increasing number of disease-years
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DOI：
10.1179/147683008x301441
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发表时间：
2008-06-01
影响因子：
3.6
通讯作者：
Pezzoli, Gianni
中科院分区：
文献类型：
--
作者：
Barichella, Michela;Villa, Maria Chiara;Pezzoli, Gianni
目的：为了监测帕金森病患者的营养状况，使用迷你营养评估（MNA）questionnaire.Patients和方法：这是一项为期3年的纵向研究，在国家转诊中心进行帕金森病和其他运动障碍。该队列包括61名帕金森病患者，37名男性和24名女性，平均年龄70.5 ± 5.5岁，平均病程9 ± 6.3年; 35名患者在3年后随访。（P = 0.02）;营养不良风险的患者比例从22.9%增加到34.3%。MNA评分与病程呈直线相关（P = 0.0096）。饮食评估分项评分显著降低（8.6对8.1; P = 0.0009），体重指数也显著降低（25.9 +/- 3.5 kg/m2对27.1 +/- 3.1 kg/m2; P = 0.001）。结论：营养状况评估应成为帕金森病患者常规检查的一部分。饮食教育应包括在旨在改善帕金森病的一般条件的治疗措施。
Objective: To monitor the nutritional status of patients with Parkinson's disease using the Mini Nutritional Assessment (MNA) questionnaire.Patients and methods: This was a 3-year longitudinal study conducted in a national referral centre for Parkinson's disease and other movement disorders. The cohort included 61 Parkinson's disease patients, 37 men and 24 women, mean age of 70.5 +/- 5.5 years, mean duration of disease 9 +/- 6.3 years; 35 patients were followed-up after 3 years.Results: MNA score diminished from 24.9 +/- 1.6 to 24 +/- 2.5 (P = 0.02); the proportion of patients at risk of malnutrition increased from 22.9% to 34.3%. A linear correlation was observed between MNA score and the duration of disease (P = 0.0096). The dietary assessment subscore significantly diminished (8.6 versus 8.1; P = 0.0009) as did body mass index (25.9 +/- 3.5 kg/m(2) versus 27.1 +/- 3.1 kg/m(2); P = 0.001).Conclusions: The evaluation of nutritional status should be part of the routine work-up of a Parkinson's disease patient. Dietary education should be included amongst the therapeutic measures designed to improve the general conditions in Parkinson's disease.