Increased population prevalence of reflux and obesity in the United Kingdom compared with Sweden: a potential explanation for the difference in incidence of esophageal adenocarcinoma
Increased population prevalence of reflux and obesity in the United Kingdom compared with Sweden: a potential explanation for the difference in incidence of esophageal adenocarcinoma
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DOI：
10.1097/meg.0b013e3283424e25
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发表时间：
2011-02-01
影响因子：
2.1
通讯作者：
Lagergren, Jesper
中科院分区：
文献类型：
--
作者：
Lofdahl, Hedvig E.;Lane, Athene;Lagergren, Jesper
食管腺癌的发病率在英国是瑞典的5倍。我们研究了食管腺癌的患病率，建立的危险因素在两个population.Methods人口为基础的横断面研究比较流行的胃食管反流症状，肥胖，吸烟之间的随机抽样的英国和瑞典的人口年龄在40-59岁。通过自我报告问卷收集数据。多变量Logistic回归得出的比值比与95%的置信区间，调整潜在的confounding.Results样本由3633英语和1483瑞典人（响应率分别为43和62%）。至少每周发生一次的反流症状的患病率是瑞典样本的两倍。肥胖（BMI >= 30）在英国样本中也几乎是两倍。吸烟的频率在这两个国家是相似的。反流症状和BMI至少为25的组合是三倍更常见的英语比在瑞典sample.Conclusion的反流症状和肥胖的样本中的英语人口与瑞典人口相比，显著较高的患病率可能有助于已知的食管腺癌的发病率较高，在英国。Eur J Gastroenterol Hepatol 23：128-132（C）2011 Wolters Kluwer Health竖条Lippincott威廉姆斯&威尔金斯。
Objectives The incidence of esophageal adenocarcinoma is five times higher in the UK than in Sweden. We examined the prevalence of established risk factors for esophageal adenocarcinoma in both populations.Methods A population-based cross-sectional study comparing the prevalence of gastroesophageal reflux symptoms, obesity, and tobacco smoking between random samples of the English and Swedish populations aged 40-59 years. Data were collected through self-report questionnaires. Multivariable logistic regression yielded odds ratios with 95% confidence intervals, adjusting for potential confounding.Results The sample was composed of 3633 English and 1483 Swedish people (response rates 43 and 62%, respectively). The prevalence of reflux symptoms occurring at least weekly was twice as common in the English compared with the Swedish sample. Obesity (BMI >= 30) was also nearly two-fold more common in the English sample. The frequency of tobacco smoking was similar in both countries. The combination of reflux symptoms and a BMI of at least 25 was three-fold more common in the English than in the Swedish sample.Conclusion The substantially higher prevalence of reflux symptoms and obesity in samples of the English population compared with the Swedish population might contribute to the known higher incidence of esophageal adenocarcinoma in the UK. Eur J Gastroenterol Hepatol 23:128-132 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.