Delayed appearance of liver growth hormone binding sites and of growth hormone-induced somatomedin production during rat development.
Delayed appearance of liver growth hormone binding sites and of growth hormone-induced somatomedin production during rat development.
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在大鼠发育过程中，肝脏生长激素结合位点和生长激素诱导的生长调节素产生的延迟出现。
DOI：
10.1016/0006-291x(86)90873-9
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发表时间：
1986
影响因子：
3.1
通讯作者：
E. Blázquez
中科院分区：
文献类型：
--
作者：
B. Flández;E. Álvarez;E. Blázquez
本研究的目的是确定是否明显矛盾的高循环生长激素水平在胎儿和这种激素对生长的影响最小可能反映胎儿靶器官GH的反应性降低。与哺乳期和成年大鼠相比，胎鼠的[125I] bGH的大鼠肝脏特异性摄取非常低。此外，肝脏摄取的碘化激素下降成比例的同时注射的生长激素的量增加，但没有修改的同时注射未标记的化学相关的激素。由于胎儿组织中的含水量显著高于成人组织，因此结果以肝脏干重表示，并且[125I] bGH肝脏摄取量再次随年龄增加而持续增加。成年大鼠给予牛生长激素后，血浆生长调节素C浓度显著升高，而对胎鼠无影响。这些结果表明，减少肝脏体细胞结合位点的胎儿阻止生长激素诱导生长促进作用在宫内生活。
The present study was designed to determine whether the apparent paradox of high circulating growth hormone levels in the fetus and the minimal effect of this hormone on growth might reflect a diminished responsiveness of fetal target organs to GH. Specific uptake by rat liver of [125I] bGH was very low in fetuses as compared to suckling and adult rats. Also, liver uptake of the iodinated hormone decreased proportionally with the simultaneous injection of increasing amounts of growth hormone, but was not modified by the simultaneous injection of unlabelled chemically-related hormones. Since the water content is significantly greater in fetal than adult tissues, results were expressed by liver dry weight and again, [125I] bGH liver uptake continued to increase with age. After bovine growth hormone administration to adult rats, plasma somatomedin C concentrations increased significantly, while they had no effect in fetuses. These results suggest that reduced liver somatogenic binding sites in the fetus prevents growth hormone from inducing growth-promoting effects during intrauterine life.
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高亲和力胰岛素受体介导大鼠肝癌细胞的生长刺激。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Massagué,J;Blinderman,LA;Czech,MP
通讯作者：
Czech,MP
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影响因子：
4.8
作者：
Freemark,M;Handwerger,S
通讯作者：
Handwerger,S
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影响因子：
4.8
作者：
Richman,RA;Benedict,MR;Florini,JR;Toly,BA
通讯作者：
Toly,BA
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影响因子：
6.1
作者：
Hurley,TW;Kuhn,CM;Schanberg,SM;Handwerger,S
通讯作者：
Handwerger,S