Indocyanine-green-assisted internal limiting membrane peeling in macular hole surgery – a follow-up study
Indocyanine-green-assisted internal limiting membrane peeling in macular hole surgery – a follow-up study
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吲哚菁绿辅助黄斑裂孔手术中的内界膜剥离——一项后续研究
DOI：
10.1007/s00417-002-0544-1
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
N. Schrage
中科院分区：
文献类型：
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作者：
A. Weinberger;B. Schlossmacher;C. Dahlke;M. Hermel;B. Kirchhof;N. Schrage
摘要背景：黄斑裂孔手术包括玻璃体切除、视网膜前膜和内界膜剥离，已成为视网膜手术的标准操作。ILM的可视化差是手术成功的障碍。最近，吲哚菁绿色（ICG）已被报道是一种有用的眼内物质，在识别这些膜。术中，用3滴1：9稀释的ICG对ILM进行染色。孵育1分钟后，用林格氏乳酸盐溶液冲洗玻璃体腔，并剥离ILM。自体血小板应用于黄斑裂孔，眼内填充20%SF-6气体。术前，术后6周，并在3个月的时间间隔，此后，视力，眼底照片，扫描激光检眼镜成像，和Humphrey 24-2静态perimetry perimetry.Results. Intraoperative，ILM可以很好地可视化ICG，这允许更容易和创伤性剥离。在6周随访时，18例患者中有14例视力提高，黄斑裂孔在术后6周闭合。扫描激光成像显示了强烈的信号。结论：ICG作为一种眼内工具对ILM进行染色有助于黄斑裂孔手术。我们没有观察到对视网膜功能的负面影响，但患者应进行随访。
AbstractBackground.Macular hole surgery including vitrectomy and peeling of epiretinal membranes and the internal limiting membrane (ILM) has become a standard procedure in retinal surgery. Poor visualization of the ILM is an obstacle for successful surgery. Recently, indocyanine green (ICG) has been reported to be a helpful intraocular substance in identifying these membranes.Patients and methods.Eighteen eyes with macular holes stages 2–4 were included. Intraoperatively, the ILM was stained with three drops of 1:9-diluted ICG. After 1 min incubation, the vitreous cavity was rinsed with Ringer's lactate solution, and the ILM was peeled. Autologous thrombocytes were applied to the macular hole and the eye was endotamponaded with 20% SF-6 gas. Preoperatively, 6 weeks postoperatively, and in 3-month intervals thereafter, visual acuity, fundus photographs, scanning laser ophthalmoscope imaging, and Humphrey 24–2 static perimetry was performed.Results.Intraoperatively, the ILM could be nicely visualized by ICG, which allowed easier and less traumatic peeling. At 6 weeks follow-up, visual acuity had improved in 14 of 18 patients, and the macular hole was closed 6 weeks after surgery. Scanning laser imaging revealed a strong signal. During prolonged follow-up, visual acuity declined due to cataract formation.Conclusion.ICG as an intraocular tool for staining of the ILM is helpful in macular hole surgery. We observed no negative effects on retinal function, but patients should be followed.