Design of a sustainable prepolarizing magnetic resonance imaging system for infant hydrocephalus.
Design of a sustainable prepolarizing magnetic resonance imaging system for infant hydrocephalus.
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DOI：
10.1007/s10334-018-0683-y
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Schiff SJ
中科院分区：
文献类型：
--
作者：
Obungoloch J;Harper JR;Consevage S;Savukov IM;Neuberger T;Tadigadapa S;Schiff SJ
由于能源供应不足、技术专长有限和基础设施落后等挑战持续存在，发展中国家对负担得起的适当医疗技术的需求继续增加。低场磁共振成像（LF MRI）是一种可以定制以满足这些国家特定成像需求的技术。其低功耗要求和在最低屏蔽或无屏蔽环境中工作的可能性使其特别具有吸引力。尽管该技术已经被广泛证明了几十年，但尚未证明它可以在临床应用中诊断和改善患者的预后。我们在这里展示了预极化MRI（PMRI）技术在发展中国家组装和部署的稳健性，以用于婴儿脑积水的特定应用。脑积水的治疗计划和管理只需要适度的空间分辨率，这样大脑就可以从脑实质内的液体-组织对比细节中区分出来。我们构建了一个内部屏蔽的PMRI系统的基础上的李-怀汀线圈系统与22厘米直径的球形体积。在非屏蔽室中，通过引入足够大的梯度场来控制读出场的5000 ppm不均匀性，以113 kHz采集投影体模图像，面内分辨率为3 mm × 3 mm。低成本，简单的组装，部署潜力和维护要求证明了我们的PMRI系统对发展中国家的适用性。LF MRI图像空间分辨率和对比度的进一步提高将扩大其潜在的临床应用范围，而不仅仅局限于脑积水。
The need for affordable and appropriate medical technologies for developing countries continues to rise as challenges such as inadequate energy supply, limited technical expertise, and poor infrastructure persist. Low-field magnetic resonance imaging (LF MRI) is a technology that can be tailored to meet specific imaging needs within such countries. Its low power requirements and the possibility of operating in minimally shielded or unshielded environments make it especially attractive. Although the technology has been widely demonstrated over several decades, it is yet to be shown that it can be diagnostic and improve patient outcomes in clinical applications. We here demonstrate the robustness of prepolarizing MRI (PMRI) technology for assembly and deployment in developing countries for the specific application to infant hydrocephalus. Hydrocephalus treatment planning and management requires only modest spatial resolution, such that the brain can be distinguished from fluid—tissue contrast detail within the brain parenchyma is not essential. We constructed an internally shielded PMRI system based on the Lee-Whiting coil system with a 22-cm diameter of spherical volume. In an unshielded room, projection phantom images were acquired at 113 kHz with in-plane resolution of 3 mm × 3 mm, by introducing gradient fields of sufficient magnitude to dominate the 5000 ppm inhomogeneity of the readout field. The low cost, straightforward assembly, deployment potential, and maintenance requirements demonstrate the suitability of our PMRI system for developing countries. Further improvement in image spatial resolution and contrast of LF MRI will broaden its potential clinical utility beyond hydrocephalus.
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