Transposon-like Correia elements:: Structure, distribution and genetic exchange between pathogenic Neisseria sp.
Transposon-like Correia elements:: Structure, distribution and genetic exchange between pathogenic Neisseria sp.
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DOI：
10.1016/s0014-5793(02)02882-x
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发表时间：
2002-07-03
期刊：
影响因子：
3.5
通讯作者：
Chalmers, R
中科院分区：
文献类型：
--
作者：
Buisine, N;Tang, CM;Chalmers, R
Correia元件是所有四种奈瑟氏菌基因组序列的突出特征。我们报告了这些元素的结构和基因组分布的计算机分析和一些初步的生化数据。Correia元件分为四个主要的家族，其区别在于50 bp的内部缺失和五个点突变。这些元件类似于在靶位点具有25 bp反向重复和TA重复的转座子。在该元件内存在功能整合宿主因子结合位点。Correia元件的基因组分布基本上是随机的，除了一些小的Correia的区域显然是通过水平转移获得的。系统发育分析表明，它们的存在早于脑膜炎奈瑟菌和淋病奈瑟菌的分歧。(C)2002年欧洲生物化学学会联合会。由Elsevier Science B.V.出版，版权所有。
Correia elements are a prominent feature of all four Neisseria genome sequences. We report an in silico analysis of the structure and genomic distribution of these elements and some preliminary biochemical data. Correia elements fall into four major families, distinguished by a 50 bp internal deletion and five point mutations. The elements resemble a transposon with 25 bp inverted repeats and a TA duplication at the target site. Within the element there is a functional integration host factor binding site. The genomic distribution of Correia elements is essentially random except for some small Correia-less regions apparently acquired by horizontal transfer. Phylogenetic analysis suggests that their presence predates the divergence of Neisseria meningitidis and Neisseria gonorrhoeae. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.