Contrasting responses by basal ganglia met-enkephalin systems to low and high doses of methamphetamine in a rat model
Contrasting responses by basal ganglia met-enkephalin systems to low and high doses of methamphetamine in a rat model
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DOI：
10.1046/j.1471-4159.2001.00043.x
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发表时间：
2001-02-01
影响因子：
4.7
通讯作者：
Hanson, GR
中科院分区：
文献类型：
--
作者：
Alburges, ME;Keefe, KA;Hanson, GR
通过测定甲基苯丙胺（METH）单次低剂量（0.5mg/kg）或高剂量（10 mg/kg）给药后纹状体、苍白球和黑质区甲硫脑啡肽（Menk）的含量，研究了METH对基底节甲硫脑啡肽（Menk）的影响。低剂量和高剂量METH治疗后，纹状体和苍白球区的Menk水平分别降低和升高，给药后12小时，所有纹状体和苍白球区检查。双剂量效应似乎主要受多巴胺D-2样受体激活增加的影响，而高剂量效应似乎是由D-1样受体激活占主导地位造成的。然而，这两种效应都需要D-1和D-2样受体的共激活。在大多数情况下，无论是低剂量和高剂量的甲基苯丙胺诱导的变化，在Menk组织含量完全恢复到24小时。METH处理后3-24 h，黑质中的Menk水平没有显著改变。本文报道的结果表明，纹状体和苍白球Menk通路在用低剂量或高剂量的METH急性治疗后反应不同。
The influence of methamphetamine (METH) on basal ganglia met-enkephalin (Menk) was studied by determining levels of this peptide in striatal, pallidal and nigral regions after administering a single low (0.5.mg/kg) or high (10 mg/kg) dose of this stimulant. The Menk levels in the striatal and pallidal areas were reduced and increased after the low- and high-dose METH treatments, respectively, 12 h after drug administration in all striata[ and pallidal regions examined. The tow-dose effect appeared to be principally influenced by increased activation of the dopamine D-2-like receptor, while the high-dose effect seemed to result from dominance of D-1-like receptor activation. However, both effects required coactivation of D-1- and D-2-like receptors. For the most part, both low- and high-dose METH-induced changes in Menk tissue content were fully recovered by 24 h. The Menk levels were not significantly altered in the substantia nigra 3-24 h after either METH treatment. Results reported herein indicated that striatal and pallidal Menk pathways respond differently after acute treatment with low or high doses of METH.