The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer
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WWOX 的下调诱导上皮-间质转化并增强乳腺癌的干细胞性和化疗耐药性
DOI：
10.1177/1535370218806455
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发表时间：
2018-09-01
影响因子：
3.2
通讯作者：
Liu, Peijun
中科院分区：
文献类型：
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作者：
Li, Juan;Liu, Jie;Liu, Peijun
含WW结构域的氧化还原酶（WWOX）是一种重要的肿瘤抑制因子，在调节细胞增殖和凋亡中起重要作用。我们的研究表明，低水平的WWOX与三阴性乳腺癌亚型（TNBC）相关，TNBC具有较高的干细胞表型和化疗耐药性。我们评估了WWOX在乳腺癌干细胞（BCSC）表型和化疗耐药性调节中的作用。我们的研究结果表明，敲低WWOX增加了乳腺癌细胞的干细胞性。同时，下调WWOX可诱导乳腺癌细胞系的上皮-间质转化（EMT）和化疗耐药性。我们的研究结果揭示了WWOX在调节BCSC群体和化疗敏感性中的作用，并可能为开发更有效的靶向乳腺癌干细胞的治疗方法提供见解。
WW domain-containing oxidoreductase (WWOX), an important tumor suppressor, is essential for regulating cell proliferation and apoptosis. Our study demonstrates that low level of WWOX is associated with the triple-negative subtype of breast cancer (TNBC), which has higher stem cell phenotype and chemoresistance. We evaluated the role of WWOX in regulation of breast cancer stem cells (BCSC) phenotype and chemoresistance. Our results showed that knockdown of WWOX increases the stemness of breast cancer cells. Meanwhile, downregulation of WWOX induces the epithelial-mesenchymal transition (EMT) and chemoresistance of breast cancer cell lines. Our findings revealed the role of the WWOX in the regulation of the BCSC population and chemotherapeutic sensitivity and may provide insights for the development of more effective therapies targeting cancer stem cells in breast cancer.