Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study
Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study
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较低的 CH50 作为难治性或复发性狼疮性肠炎的预测因子：一项回顾性观察研究
DOI：
10.1080/14397595.2020.1812871
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发表时间：
2021
影响因子：
2.2
通讯作者：
Eiji Sugiyama
中科院分区：
文献类型：
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作者：
Yusuke Yoshida;Takuji Omoto;Hiroki Kohno;Tadahiro Tokunaga;Tatsuomi Kuranobu;Kazutoshi Yukawa;Hirofumi Watanabe;Katsuhiro Oi;Tomohiro Sugimoto;Sho Mokuda;Takaki Nojima;Shintaro Hirata;Eiji Sugiyama
狼疮性肠炎（LE）是系统性红斑狼疮（SLE）的一种罕见但常见的胃肠道表现。进行这项研究，以确定与LE.MethodsWe连续登记诊断为LE的患者之间的2009年1月和2019年10月的不良反应的预后因素，并回顾性比较他们的临床特征的基础上，他们是否有良好或不良反应的treatment.ResultsA共13例（17集）被列入。中位年龄为41岁，12例患者为女性。两组之间的临床特征比较显示了相似的计算机断层扫描（CT）结果。然而，低应答组的血清CH 50水平显著较低（中位数[四分位距（IQR）]; 29.2 [25.3-46.9] U/mL vs 19.3 [7.8-24.0] U/mL，p= 0.0095）。低反应组中更多患者的抗心磷脂β2-糖蛋白I抗体（抗CL β2GPI Ab）滴度较高，并开始接受中等剂量的糖皮质激素（GC）治疗。在多变量分析中，血清CH 50水平是独立相关的不良反应诱导therapy.ConclusionLower水平的CH 50在初始治疗时预测不充分的治疗反应LE患者。
ObjectivesLupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE.MethodsWe consecutively registered patients diagnosed with LE between January 2009 and October 2019, and retrospectively compared their clinical characteristics based on whether they had good or poor responses to treatment.ResultsA total of 13 patients (17 episodes) were included. The median age was 41 years, and 12 patients were female. A comparison of clinical characteristics between groups revealed similar computed tomography (CT) findings. However, serum CH50 levels were significantly lower in the poor response group (median [interquartile ranges (IQR)]; 29.2 [25.3–46.9] U/mL vs 19.3 [7.8–24.0] U/mL,p= .0095). More patients in the poor response group had higher titers of anti-cardiolipin β2-glycoprotein I antibody (anti-CL β2GPI Ab) and were started on glucocorticoids (GCs) at moderate doses. In multivariable analysis, serum CH50 level was independently associated with poor response to induction therapy.ConclusionLower levels of CH50 at the time of initial treatment predicted inadequate treatment response in patients with LE.
一名系统性红斑狼疮患者在治疗慢性狼疮性腹膜炎期间出现大面积小肠出血
影响因子：
2.2
作者：
S. Kawashiri;A. Nishino;E. Sueyoshi;A. Okada;T. Koga;S. Yamasaki;Hideki Nakamura;T. Origuchi;A. Kawakami
通讯作者：
A. Kawakami
复发性狼疮肠系膜血管炎导致胃肠道穿孔和败血症
影响因子：
3.3
作者：
Ying;I. Huang;Wen‐Bin Feng;Y. Chiou
通讯作者：
Y. Chiou
影响因子：
--
作者：
Furie, Richard A.;Petri, Michelle A.;Wallace, Daniel J.;Ginzler, Ellen M.;Merrill, Joan T.;Stohl, William;Chatham, W. Winn;Strand, Vibeke;Weinstein, Arthur;Chevrier, Marc R.;Zhong, Z. John;Freimuth, William W.
通讯作者：
Freimuth, William W.