Pectin in diet: Interactions with the human microbiome, role in gut homeostasis, and nutrient-drug interactions
Pectin in diet: Interactions with the human microbiome, role in gut homeostasis, and nutrient-drug interactions
复制标题
DOI：
10.1016/j.carbpol.2020.117388
复制
发表时间：
2021-01-09
影响因子：
11.2
通讯作者：
Farag, Mohamed A.
中科院分区：
文献类型：
--
作者：
Elshahed, Mostafa S.;Miron, Anca;Farag, Mohamed A.
果胶是日常饮食的一部分，也是食品添加剂，是人体酶难以消化的多糖，然而，它们可以很容易地被肠道细菌降解，产生短链脂肪酸（SCFA）。关于果胶肠道内稳态以及果胶如何影响肠道细菌群落的知识是不充分和有限的。这篇综述的重点是提供果胶如何在肠道中作为益生元发挥作用的整个故事。了解动物或人类肠道内的功能和免疫反应之间的相互作用，受膳食中果胶的影响。果胶和肠道微生物群之间的相互作用从两个方面提出，即果胶如何影响肠道微生物组和/或肠道细菌响应产生的发酵产物。这些知识可用于定义首选的膳食果胶，靶向有益细菌，并有利于肠道中平衡的微生物群，以最大限度地发挥果胶的健康益处。
Pectins are a part of daily diet as well as food additives that are indigestible polysaccharides by human enzymes, however, they can be easily degraded by gut bacteria with the production of short chain fatty acids (SCFAs). Knowledge of pectin gut homeostasis and further how pectin affect gut bacterial communities is insufficient and limited. This review focuses on providing the whole story of how pectin functions as prebiotics in the gut. Understanding the interplay between functional and immunological responses inside animal or human gut as influenced by pectin in diets is provided. The interaction between pectin and gut micmbiota is presented from both sides, in terms of how pectin affects gut microbiome and or the fermentation products produced in response by gut bacteria. This knowledge can be used to define preferred dietary pectins, targeting beneficial bacteria, and favoring balanced microbiota communities in the gut to maximize pectins' health benefits.