Associations of environmental and lifestyle factors with spatial navigation in younger and older adults.
Associations of environmental and lifestyle factors with spatial navigation in younger and older adults.
复制标题
DOI：
10.1017/s1355617722000303
复制
发表时间：
2023-05
影响因子：
2.6
通讯作者：
Head, Denise
中科院分区：
文献类型：
--
作者：
Maybrier, Hannah;Palanca, Ben Julian A.;Head, Denise
高龄与依赖于海马的非中心导航的显著损害相关。本研究探讨了年龄相关的损伤，在allocentric导航和策略选择是否与睡眠中断或昼夜休息活动片段。此外，我们研究了与导航的关联是否受到感知压力和体力活动的调节。通过腕关节活动记录仪，对年轻（n=42）和老年（n=37）成人在1周内的睡眠片段和总睡眠时间进行了分析。随后，参与者完成认知地图和路线学习任务，以及自发导航策略选择的措施。还获得了感知压力和基于活动记录的身体活动指数的测量结果。通过事后腕动计估计昼夜休息-活动片段。年龄与认知映射、路线学习、以他为中心的策略使用和总睡眠时间减少相关（ps<.01），重复了先前的研究结果。新的发现包括睡眠碎片随着年龄的增长而增加（p= 0.009），并且与老年人队列中较低的认知映射（p= 0.022）相关。总睡眠时间与导航任务没有线性关系（ps> 0.087）。事后分析显示，昼夜节律的休息-活动片段随着老年人年龄的增长而增加（p= 0.026），并与整个生命周期（p= 0.001）和老年人（p= 0.005）中较低的认知映射相关。无论是压力还是体力活动都不是睡眠碎片与导航任务之间关系的有力调节因素（ps> 0.113）。睡眠片段化和昼夜休息-活动片段化是老年人认知图年龄效应的潜在影响因素。
Advanced age is associated with prominent impairment in allocentric navigation dependent on the hippocampus. This study examined whether age-related impairment in allocentric navigation and strategy selection was associated with sleep disruption or circadian rest-activity fragmentation. Further, we examined whether associations with navigation were moderated by perceived stress and physical activity. Sleep fragmentation and total sleep time over the course of 1-week were assayed in younger (n=42) and older (n=37) adults via wrist actigraphy. Subsequently, participants completed cognitive mapping and route learning tasks, as well a measure of spontaneous navigation strategy selection. Measurements of perceived stress and an actigraphy-based index of physical activity were also obtained. Circadian rest-activity fragmentation was estimated via actigraphy post-hoc. Age was associated with reduced cognitive mapping, route learning, allocentric strategy use, and total sleep time (ps<.01), replicating prior findings. Novel findings included that sleep fragmentation increased with advancing age (p=.009) and was associated with lower cognitive mapping (p=.022) within the older adult cohort. Total sleep time was not linearly associated with the navigation tasks (ps>.087). Post-hoc analyses revealed that circadian rest-activity fragmentation increased with advancing age within the older adults (p=.026) and was associated with lower cognitive mapping across the lifespan (p=.001) and within older adults (p=.005). Neither stress nor physical activity were robust moderators of sleep fragmentation associations with the navigation tasks (ps>.113). Sleep fragmentation and circadian rest-activity fragmentation are potential contributing factors to age effects on cognitive mapping within older adults.