THE LONGITUDINAL STABILITY OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA - MINI-MENTAL STATE SCORES AT ONE-YEAR AND 2-YEAR FOLLOW-UPS IN GERIATRIC INPATIENTS
THE LONGITUDINAL STABILITY OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA - MINI-MENTAL STATE SCORES AT ONE-YEAR AND 2-YEAR FOLLOW-UPS IN GERIATRIC INPATIENTS
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DOI：
10.1192/bjp.166.5.630
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发表时间：
1995-05-01
影响因子：
10.5
通讯作者：
DAVIDSON, M
中科院分区：
文献类型：
--
作者：
HARVEY, PD;WHITE, L;DAVIDSON, M
背景严重的认知功能障碍影响许多精神分裂症患者，尤其是老年住院患者。鲜为人知的是，这种损害的过程中，然而。对224例老年精神分裂症住院患者进行了为期一年的随访，其中45例进行了为期两年的评估。此外，45名患者的子集参加了一个为期一周和一个月的测试-重测信度研究的工具，用于评估认知功能障碍，简易精神状态检查（MMSE）。平均MMSE评分在一年或两年的随访期内没有变化。量表的重测信度在两个重测区间都非常好。这些数据的含义之一是，老年精神分裂症患者的认知变化是非常缓慢的，更符合神经发育过程比神经退行性过程。
Background. Severe cognitive impairment affects many patients with schizophrenia, especially geriatric in-patients. Little is known about the course of this impairment, however.Method. Two hundred and twenty-four geriatric schizophrenic in-patients were examined for changes in cognitive functioning over a one-year follow-up period, and 45 of them were assessed over a two-year period. In addition, the subset of 45 patients participated in a one-week and one-month test-retest reliability study of the instrument used to assess cognitive impairment, the Mini-Mental State Examination (MMSE).Results. The average MMSE scores did not change over a one- or two-year follow-up period. The test-retest reliability of the scale was extremely good at both retest intervals.Conclusion. Among the implications of these data are that cognitive changes in geriatric schizophrenic patients are very slow and are more consistent with a neurodevelopmental process than a neurodegenerative course.