Development of a High-intensity Focused Ultrasound Exposure Device for Reducing Skin Burn Risk
Development of a High-intensity Focused Ultrasound Exposure Device for Reducing Skin Burn Risk
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DOI：
10.15369/sujms.32.1
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
S. Nishii;K. Seo;Aleksander Tatsuya Izdebski;M. Kushima;R. Takagi;S. Yoshizawa;S. Umemura;K. Ichizuka;A. Sekizawa
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文献类型：
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作者：
S. Nishii;K. Seo;Aleksander Tatsuya Izdebski;M. Kushima;R. Takagi;S. Yoshizawa;S. Umemura;K. Ichizuka;A. Sekizawa
：高强度聚焦超声波（HIFU）可以无创地照射体内。然而，当用于治疗胎儿时，可能会导致母亲腹壁皮肤界面处的热烧伤。这项研究的目的是确定改进的 HIFU 换能器是否可以进行分孔照射，以防止热烧伤。对两种 HIFU 换能器进行了比较：使用全孔径照射的传统换能器和使用分孔径照射的改良换能器。改进后的换能器分为6个扇区进行分孔径照射，并且比传统换能器具有更大的表面积和更小的F数（焦距/孔径直径）。在全身麻醉下，对三个月大的小猪的左腿和右腿的八个部位进行 HIFU 治疗，并由两名或多名皮肤科医生对这些部位进行热灼伤评估。同一个人进行了所有照射。传统换能器的全孔径照射会导致所有目标部位的深度真皮烧伤，而改良换能器的分孔径照射仅导致表皮烧伤或浅层真皮烧伤。使用具有六个扇区和更小的 F 值的改良 HIFU 换能器进行分孔径照射可降低皮肤烧伤的严重程度，从而提高 HIFU 治疗的安全性。
: High-intensity focused ultrasound （ HIFU ） can non-invasively irradiate inside the body. However, when used to treat fetuses, it can cause thermal burns of the mother ʼ s abdominal wall at the skin interface. This study was carried out to determine whether a modified HIFU transducer enabling split-aperture irradiation can prevent thermal burns. Two HIFU transducers were compared: a conventional transducer using full-aperture irradiation and a modified transducer using split-aperture irradiation. The modified transducer was divided into six sectors for split-aperture irradiation and had a larger surface area and a smaller F number （ focal length / aperture diameter ） than the conventional transducer. HIFU was delivered to eight sites on the left and right leg of a three-month-old baby pig under general anesthesia, and the sites were assessed for thermal burning by two or more derma-tologists. The same person performed all irradiations. Full-aperture irradiation with the conventional transducer caused deep dermal burns at all target sites, while split-aperture irradiation with the modified transducer caused only epidermal burns or superficial dermal burns. Split-aperture irradiation using a modified HIFU transducer with six sectors and a smaller F number reduces the severity of skin burns, and thus will improve the safety of HIFU therapy.