GDF15 promotes EMT and metastasis in colorectal cancer.
GDF15 promotes EMT and metastasis in colorectal cancer.
复制标题
GDF15促进结直肠癌的EMT和转移
DOI：
10.18632/oncotarget.6205
复制
发表时间：
2016-01-05
期刊：
影响因子：
--
通讯作者：
Lai M
中科院分区：
文献类型：
--
作者：
Li C;Wang J;Kong J;Tang J;Wu Y;Xu E;Zhang H;Lai M
转移是癌症死亡的主要原因，而上皮-间充质转化(EMT)被认为是肿瘤转移的基础事件。然而，生长分化因子15(GDF15)在结直肠癌(CRC)转移和EMT中的作用仍然知之甚少。在此，我们发现GDF15在体外和体内都促进了结直肠癌细胞的转移。此外，GDF15通过与转化生长因子-β受体结合，激活Smad2和Smad3通路，促进内皮细胞转导过程。临床资料显示，肿瘤组织中GDF15水平升高，血清GDF15水平明显升高，其中GDF15水平高与结直肠癌患者总生存期减少相关。因此，GDF15可能通过激活EMT促进结直肠癌的转移。GDF15有望成为临床上判断结直肠癌预后的新指标。
Metastasis is the major cause of cancer deaths, and the epithelial–mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathways. Clinical data showed GDF15 level in tumor tissues, and the serum was significantly increased, in which high GDF15 level correlated with a reduced overall survival in CRC. Thus, GDF15 may promote colorectal cancer metastasis through activating EMT. Promisingly, GDF15 could be considered as a novel prognostic marker for CRC in the clinic.