Intracellular signalling cascades activated by the EGF receptor and/or by integrins, with potential relevance for branching morphogenesis of the fetal mouse submandibular gland.
Intracellular signalling cascades activated by the EGF receptor and/or by integrins, with potential relevance for branching morphogenesis of the fetal mouse submandibular gland.
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由 EGF 受体和/或整联蛋白激活的细胞内信号级联，与胎儿小鼠颌下腺的分支形态发生具有潜在相关性。
DOI：
10.1076/0924-3860(200010)38:4;1-o;ft269
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Gresik,EW
中科院分区：
文献类型：
--
作者：
Kashimata,MW;Sakagami,HW;Gresik,EW
胎鼠下颌下腺是一个研究上皮-间充质相互作用的重要模型。这个基本的发育过程依赖于生长因子和细胞外基质成分的受体的同时参与。在这里，我们审查细胞内的信号级联介导的EGFR在发育中的小鼠颌下腺的激活。
The fetal mouse submandibular gland grown in vitro is a valuable model system to study epithelio-mesenchymal interactions vital for branching morphogenesis. This basic developmental process is dependent upon simultaneous engagement of receptors for growth factors and components of the extracellular matrix. Here we review intracellular signalling cascades mediated by activation of the EGFR in the developing mouse submandibular gland.