A wireless implantable switched-capacitor based optogenetic stimulating system.
A wireless implantable switched-capacitor based optogenetic stimulating system.
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DOI：
10.1109/embc.2014.6943731
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ghovanloo M
中科院分区：
文献类型：
--
作者：
Lee HM;Kwon KY;Li W;Ghovanloo M
本文提出了一种使用基于无线开关电容器的刺激（SCS）系统的功率高效的植入式光遗传学接口。SCS直接从感应链路对存储电容器进行有效充电，并定期将其放电到微发光二极管阵列中，从而提供高瞬时功率，而不会影响无线链路和系统电源电压。LabVIEW环境中的定制设计的计算机接口通过感应链路无线控制刺激参数，并且光极阵列能够与光学刺激同时沿着进行神经记录。采用0.35 μ mCMOS工艺实现了4通道SCS系统原型，并与光电管阵列相结合。涉及光诱导局部场电位的体内实验验证了SCS系统的功效。正在开发具有柔性气密密封的SCS系统的植入式版本，用于长期实验。
This paper presents a power-efficient implantable optogenetic interface using a wireless switched-capacitor based stimulating (SCS) system. The SCS efficiently charges storage capacitors directly from an inductive link and periodically discharges them into an array of micro-LEDs, providing high instantaneous power without affecting wireless link and system supply voltage. A custom-designed computer interface in LabVIEW environment wirelessly controls stimulation parameters through the inductive link, and an optrode array enables simultaneous neural recording along with optical stimulation. The 4-channel SCS system prototype has been implemented in a 0.35-μm CMOS process and combined with the optrode array. In vivo experiments involving light-induced local field potentials verified the efficacy of the SCS system. An implantable version of the SCS system with flexible hermetic sealing is under development for chronic experiments.