Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events
Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events
复制标题
DOI：
10.1007/bf03086239
复制
发表时间：
2009-04-01
影响因子：
2
通讯作者：
Smit, A. J.
中科院分区：
文献类型：
--
作者：
Mulder, D. J.;van Haelst, P. L.;Smit, A. J.
背景ST段抬高型心肌梗死（STEMI）与炎症和氧化应激增加有关，促进晚期糖基化终产物（AGEs）的形成。其包括特征性荧光模式，其可以作为皮肤自发荧光（AF）非侵入性地测量。在这项研究中，我们调查了ST段抬高型心肌梗死患者的皮肤AF是否升高，其与炎症和缺血性应激的关系，以及其对未来事件的预测价值。在88名STEMI患者（平均年龄64 +/-13岁）出院后72小时内和约6个月内，在81名稳定性冠状动脉疾病（sCAD）患者（64 +/-10岁）和32名健康对照（63 +/-11岁）中测量了皮肤AF。记录一年内全因死亡率和因心肌梗死或心力衰竭住院的累积发生率。与sCAD和对照组相比，STEMI患者的皮肤AF显著更高，不考虑混杂因素，并且与HbA1c和C反应蛋白相关。STEMI患者在出院后> 200天测量时，皮肤AF显著降低。在ST段抬高型心肌梗死患者中，皮肤AF高于g中位数可预测未来事件（风险比11.6，95% CI 1.5 - 90.8，p = 0.019）。结论STEMI患者的皮肤AF升高，与炎症和缺血性应激相关，并可预测未来的主要不良心脏事件。(Neth Heart J 2009; 17：162 - 8.）
Background. ST-elevation myocardial infarction Back, (STEMI) is associated with increased inflammation and oxidative stress, enhancing the formation of advanced glycation endproducts (AGEs). Thew , encompass characteristic fluorescence: pattern, which can be non-invasively measured as skin autofluorescence (AF). In this study we investigate whether skin AF is elevated in STEMI, its association with inflammatory and glycaemic stress,and its predictive value for future events.Methods. Skin AF was measured in 88 STEMI patients (mean age 64 +/- 13 years) within 72 hours and around six months after discharge, in 81 stable coronary artery disease (sCAD) patients (64 +/- 10 years), and in 32 healthy controls (63 +/- 11 years). The cumulative one-year incidence Of all-cause mortality and hospitalisation for myocardial infarction Or heart failure was documented.Results. Skin AF was significantly higher in STEMI compared with sCAD and controls, irrespective of: confounders, and was associated with HbA1c and C-reactive protein. Skin AF decreased significantly in STEMI patients, when measured >200 days after discharge. In STEMI patients, skin AF above g the median was predictive of future events (hazard ratio 11.6, 95% CI 1.5 to 90.8, p=0.019). Conclusion . Skin AF is elevated in STEMI, is associated with inflammation and glycaemic stress, and predicts future major adverse cardiac events. (Neth Heart J 2009;17:162-8.)