Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years.
Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years.
复制标题
肥胖手术导致产妇体重大幅减轻，可防止肥胖传染给儿童，并对其进行了 2 至 18 年的随访。
DOI：
10.1097/01.ogx.0000259147.93208.9f
复制
发表时间：
2007
期刊：
影响因子：
8
通讯作者：
P. Marceau
中科院分区：
文献类型：
--
作者：
J. Kral;S. Biron;S. Simard;F. Hould;S. Lebel;S. Marceau;P. Marceau
客观的
OBJECTIVE
Our aim was to compare the prevalence of obesity in 172 children who were aged 2 to 18 years and born to 113 obese mothers (BMI: 31 +/- 9 kg/m2) with substantial weight loss after biliopancreatic bypass surgery with 45 same-age siblings who were born before maternal surgery (mothers' BMI: 48 +/- 8 kg/m2) and with current population standards.
METHODS
In this case series, with >88% follow-up in a tertiary referral center, cross sectional office chart and telephone data on childhood and adolescent weights were transformed to z scores.
RESULTS
After maternal surgery, the prevalence of obesity in the offspring decreased by 52% and severe obesity by 45.1%, with no increase in the prevalence of underweight. The z score reduction in obesity was gender specific, with boys reducing from 1.4 +/- 1.3 before to 0.57 +/- 1.7 after maternal surgery, corrected for birth order. The difference was not significant in girls (0.8 +/- 1.3 vs 0.8 +/- 1.2). Among children of both genders who were aged 6 to 18 years of age and born after maternal surgery, the prevalence of overweight was reduced to population levels.
CONCLUSIONS
Contrary to outcomes after intrauterine under- and overnutrition, the prevalence of overweight and obesity in children of mothers with large voluntary postsurgical weight loss was similar to that in the general population, with no increase in underweight. The results demonstrate the importance of potentially modifiable epigenetic factors in the cause of obesity.