Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
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DOI：
10.1142/s0192415x14200018
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发表时间：
2014-01
期刊：
影响因子：
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通讯作者：
Xiao-hui Wu;Chunhao Yu;Chun-Feng Zhang;S. Anderson;Yan-Wen Zhang
中科院分区：
文献类型：
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作者：
Xiao-hui Wu;Chunhao Yu;Chun-Feng Zhang;S. Anderson;Yan-Wen Zhang
牛尾草的根和根茎，在传统中医中被称为“牛尾菜”，被认为是有效治疗痛风症状的药物。然而，尚不清楚S.河岸支持其治疗活性。在这项研究中，我们检查了S。Riparia在氧酸钾诱导的高尿酸血症小鼠模型中降低血清尿酸水平。我们观察到S.水提物可下调肾脏mURAT1表达，促进高尿酸血症小鼠肾脏尿酸排泄。这些结果表明S.结论：水鳖草可能是一种抗痛风的有效中药，其作用机制可能与提高肾脏尿酸排泄有关。
The roots and rhizomes of Smilax riparia, called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. However, it is not clear if the uricosuric mechanisms of S. riparia support its therapeutic activities. In this study, we examined the efficacy of S. riparia in reducing serum uric acid levels in a potassium oxonate-induced hyperuricemia mouse model. We observed that the total saponins of S. riparia could down-regulate renal mURAT1, resulting in the enhancement of urate excretion in the kidney of hyperuricemic mice. These results suggest that S. riparia could be an active anti-gout herbal medicine, which would contribute to the enhancement of uric acid excretion in the kidney.