Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective.
Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective.
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DOI：
10.1007/s11926-004-0041-0
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发表时间：
2004-08-01
影响因子：
5
通讯作者：
FitzGerald, Oliver
中科院分区：
文献类型：
--
作者：
Kane, David;FitzGerald, Oliver
抗肿瘤坏死因子（TNF）治疗银屑病和银屑病关节炎的成功引入，使人们对这种慢性和经常致残的疾病产生了极大的兴趣。与类风湿关节炎的情况不同，在经过多年的艰苦研究证实TNF具有关键的促炎作用后，才引入抗TNF疗法，而TNF在银屑病关节炎中具有关键作用的证据却滞后。在本文中，新出现的免疫组织化学，遗传学和临床文献有关TNF在皮肤和关节的疾病表现中的作用进行了回顾，并提出了未来的研究领域。
The successful introduction of anti-tumor necrosis factor (TNF) therapies in psoriasis and psoriatic arthritis has sharpened considerable interest in this chronic and frequently disabling disease. Unlike the situation in rheumatoid arthritis, where anti-TNF therapies were introduced after years of painstaking research which confirmed a key proinflammatory role for TNF, the evidence for TNF having a key role in psoriatic arthritis has lagged behind. In this paper, the emerging immunohistochemical, genetic, and clinical literature relating to TNF's role in skin and joint manifestations of this disease is reviewed and areas for future research are suggested.