The in vivo degradation, absorption and excretion of PCL-based implant
The in vivo degradation, absorption and excretion of PCL-based implant
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DOI：
10.1016/j.biomaterials.2005.09.019
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发表时间：
2006-03-01
期刊：
影响因子：
14
通讯作者：
Wang, PY
中科院分区：
文献类型：
--
作者：
Sun, HF;Mei, L;Wang, PY
在大鼠体内观察了聚己内酯（PCL）的体内降解3年。用放射性标记法追踪PCL在大鼠体内的分布、吸收和排泄。结果表明，初始分子量（Mw）为66000的聚己内酯胶囊在2年的植入过程中形状保持完整。在30个月结束时，其断裂成低分子量（Mw = 8000）碎片。PCL分子量随时间的延长而下降，分子量的对数与时间呈线性关系。将氚标记的PCL（Mw 3000）植入大鼠皮下，以研究其吸收和排泄。植入后15天，在血浆中首次检测到放射性示踪剂。同时，从粪便和尿液中回收了放射性排泄物。植入后135天，累积92%的植入放射性示踪剂从粪便和尿液中排出。同时血浆放射性降至本底水平。器官中的放射性均接近背景水平，证实该物质不会在身体组织中累积，并且可以完全排出体外。(C)2005爱思唯尔有限公司保留所有权利。
The in vivo degradation of poly (epsilon-caprolactone)(PCL) was observed for 3 years in rats. The distribution, absorption and excretion of PCL were traced in rats by radioactive labeling. The results showed that PCL capsules with initial molecular weight (Mw) of 66000 remained intact in shape during 2-year implantation. It broke into low molecular weight (Mw = 8000) pieces at the end of 30 months. The Mw of PCL deceased with time and followed a linear relationship between log Mw and time. Tritium-labeled PCL (Mw 3000) was subcutaneous implanted in rats to investigate its absorption and excretion. The radioactive tracer was first detected in plasma 15 days after implantation. At the same time radioactive excreta was recovered from feces and urine. An accumulative 92% of the implanted radioactive tracer was excreted from feces and urine by 135 days after implantation. In the mean while, the plasma radioactivity dropped to the background level. Radioactivity in the organs was all close to the background level confirming that the material did not cumulate in body tissue and could be completely excreted. (C) 2005 Elsevier Ltd. All rights reserved.