Kidney function crucially affects B-type natriuretic peptide (BNP), N-terminal proBNP and their relationship
Kidney function crucially affects B-type natriuretic peptide (BNP), N-terminal proBNP and their relationship
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DOI：
10.1111/eci.12234
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发表时间：
2014-03-01
影响因子：
5.5
通讯作者：
Dohi, Yasuaki
中科院分区：
文献类型：
--
作者：
Takase, Hiroyuki;Dohi, Yasuaki
背景B型利钠肽（BNP）和N末端脑钠肽原（NT-proBNP）是治疗心力衰竭的重要生物标志物。两种肽在其前体proBNP裂解后分泌到循环中，并以活性形式或作为代谢物从肾脏排出。我们调查了肾功能的影响，这些peptids.Materials和methodsPlasma BNP浓度和NT-proBNP的血清浓度测定在229个门诊患者的心脏科（男/女=138/91，平均年龄= 68岁）和53个医院门诊慢性血液透析（30/23，68岁）。非透析患者的肾功能通过估计的肾小球滤过率（eGFR; mL/min/173 m（2））进行评估，并分为5个阶段。肾功能对BNP，NT-proBNP和它们之间的关系的影响investigated. ResultsEvaluation肾功能恶化增加BNP和NT-proBNP水平，以及NT-proBNP/BNP比值，这些值是最高的血液透析患者。eGFR与BNP（r=-0472）、NT-proBNP（r=-0579）、NT-proBNP/BNP比值（r=-0454，均P
BackgroundB-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are useful biomarkers in the management of heart failure. Both peptides are secreted into the circulation after cleavage of their precursor proBNP and excreted from the kidney in the active form or as metabolites. We investigated effects of kidney function on the levels and association of these peptides.Materials and methodsPlasma concentrations of BNP and serum concentrations of NT-proBNP were measured in 229 outpatients of our cardiology department (male/female=138/91, mean age=68years) and 53 hospital outpatients on chronic haemodialysis (30/23, 68years). Kidney function in nondialysed patients was assessed by estimated glomerular filtration rate (eGFR; mL/min/173m(2)) and categorised across five stages. Effects of kidney function on BNP, NT-proBNP and their relationship were investigated.ResultsDeterioration in kidney function increased BNP and NT-proBNP levels, as well as the NT-proBNP/BNP ratio, and these values were highest in patients on haemodialysis. The eGFR inversely correlated with BNP (r=-0472), NT-proBNP (r=-0579), and the NT-proBNP/BNP ratio (r=-0454, all P