Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors
Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors
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DOI：
10.1093/aje/kwh275
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发表时间：
2004-10-15
影响因子：
5
通讯作者：
Hunter, DJ
中科院分区：
文献类型：
--
作者：
Missmer, SA;Hankinson, SE;Hunter, DJ
作者在护士健康研究II前瞻性队列中调查了人口统计学、人体测量学和生活方式因素与子宫内膜异位症的关系。在10年的随访期间(1989-1999)，在没有不孕史的妇女中，报告了1721例经腹腔镜确诊的子宫内膜异位症。25-29岁的女性发病率最高，44岁以上的女性发病率最低(p(趋势)<；0.0001)。在多变量COX比例风险模型中，非裔美国女性的患病率低于高加索女性(比率比=0.6，95%可信区间：0.4，0.9)。作者还观察到，18岁时的体重指数与体重指数呈负相关(体重指数为30比19-20.4公斤/米(2)：比率=0.8，95%可信区间：0.6，1.1；p(趋势)=0.004)和当前饮酒量(10比0克/天：比率=0.7，95%可信区间：0.6，0.8；p(趋势)和lt；0.0001)，但与身高、腰臀比或咖啡因摄入量无关。只有当患者同时不育时，才能观察到与当前体重指数和当前吸烟呈负相关。作者得出结论，年龄、种族、体重指数、饮酒和吸烟与子宫内膜异位症的发病率有关，其中一些关系可能因腹腔镜诊断时的不孕状况而不同。
The authors investigated the relations of demographic, anthropometric, and lifestyle factors with endometriosis in the Nurses' Health Study II prospective cohort. During 10 years of follow-up (1989-1999), 1,721 cases of laparoscopically confirmed endometriosis were reported among women with no past infertility. The incidence rate was greatest among women aged 25-29 years and lowest among women over 44 years (p(trend) < 0.0001). In multivariate Cox proportional hazards models, African-American women had a lower rate of disease compared with Caucasian women (rate ratio = 0.6, 95% confidence interval: 0.4, 0.9). The authors also observed an inverse relation with body mass index at age 18 years (for body mass index of >30 vs. 19-20.4 kg/m(2): rate ratio = 0.8, 95% confidence interval: 0.6, 1.1; p(trend) = 0.004) and with current alcohol intake (for >10 vs. 0 g/day: rate ratio = 0.7, 95% confidence interval: 0.6, 0.8; p(trend) < 0.0001) but no association with height, waist/hip ratio, or caffeine intake. An inverse relation with current body mass index and current cigarette smoking was observed only when cases were concurrently infertile. The authors conclude that age, race, body mass index, alcohol use, and cigarette smoking are associated with the incidence of endometriosis and that some of these relations may differ by infertility status at the time of laparoscopic diagnosis.