Epidemiology of Down syndrome (trisomy 21), Hawaii, 1986-97
Epidemiology of Down syndrome (trisomy 21), Hawaii, 1986-97
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DOI：
10.1002/tera.10042
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发表时间：
2002-05-01
期刊：
影响因子：
--
通讯作者：
Merz, RD
中科院分区：
文献类型：
--
作者：
Forrester, MB;Merz, RD
背景：在美国，唐氏综合症的活产患病率约为每10,000名活产婴儿中有10名。据报道，唐氏综合症的患病率随着时间的推移而变化，并因选定的人口因素而变化。方法：来自夏威夷以人口为基础的出生缺陷登记处的数据，涉及1986-97年间出生的363例唐氏综合征病例，用于计算总体患病率，并通过选定的人口因素调查长期趋势和差异。结果：总患病率（活产、死胎和选择性终止妊娠）为14.74 / 10,000活产和死胎，未调整的活产患病率为8.67 / 10,000活产。调整后的活产（活产和预期导致活产的选择性终止妊娠的比例）流行率为每10,000活产12.59例。无论是总患病率（P = 0.688）还是调整后的活产患病率（P = 0.604），均未观察到显著的长期趋势。唐氏综合症的总患病率最高的是远东人（22.01），其次是白人（17.06），菲律宾人（15.94）和太平洋岛民（9.21）。火奴鲁鲁市区每1万名新生儿的患病率（18.57）高于夏威夷其他地区（14.15）。然而，在调整了产妇年龄后，人口统计学组内的差异没有统计学意义。结论：1986- 1997年夏威夷出生的唐氏综合症患病率低于文献报道。随着时间的推移，患病率没有显著变化。产妇种族/民族和居住地患病率的任何差异似乎都是由于产妇年龄分布的差异。(C) 2002 Wiley-Liss, Inc。
Background: The live birth prevalence of Down syndrome is approximately 10 per 10,000 live births in the United States. Down syndrome prevalence has been reported to change over time and to vary by selected demographic factors.Methods: Data from a population-based birth defects registry in Hawaii involving 363 Down syndrome cases delivered during 1986-97 were used to calculate overall prevalence and to investigate secular trends and differences by selected demographic factors.Results: The total (live birth, fetal death, and elective termination) prevalence was 14.74 per 10,000 live births and fetal deaths, The unadjusted live birth prevalence was 8.67 per 10,000 live births. The adjusted live birth (live births and proportion of elective terminations expected to have resulted in live births) prevalence was 12.59 per 10,000 live births. No significant secular trends were observed for either total prevalence (P = 0.688) or adjusted live birth prevalence (P = 0.604). The total Down syndrome prevalence per 10,000 live births was highest for Far East Asians (22.01), followed by whites (17.06), Filipinos (15.94), and Pacific Islanders (9.21). Prevalence per 10,000 births was higher in metropolitan Honolulu (18.57) than in the rest of Hawaii (14.15). After adjusting for maternal age, however, the differences within the demographic groups were not statistically significant.Conclusions: The live birth prevalence of Down syndrome in Hawaii during 1986-97 was lower than reported in the literature. Prevalence did not change significantly over time. Any differences in prevalence by maternal race/ethnicity and place of residence appeared to result from differences in maternal age distribution. (C) 2002 Wiley-Liss, Inc.