Stretchable and Transparent Metal Nanowire Microelectrodes for Simultaneous Electrophysiology and Optogenetics Applications
Stretchable and Transparent Metal Nanowire Microelectrodes for Simultaneous Electrophysiology and Optogenetics Applications
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DOI：
10.3390/photonics8060220
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发表时间：
2021-06-01
期刊：
影响因子：
2.4
通讯作者：
Lu, Luyao
中科院分区：
文献类型：
--
作者：
Tian, Jinbi;Lin, Zexu;Lu, Luyao
最近发展起来的光学透明微电极技术为体内和体外组织同时进行高分辨率的电学和光学生物接口提供了一条很有前途的途径。一个严重未得到满足的需求是设计高性能的可伸展平台，用于与机械活动的器官进行适形生物接口。在这里，我们报道了银纳米线(Ag NW)可伸缩透明微电极和互连，通过简单的选择图案化工艺，显示出优异的电学和电化学性能、高的光学透明性、卓越的机械稳定性和耐用性。该制造方法允许在弹性衬底上直接集成Ag NW网络。所得Ag NW界面的方阻(R-sh)为1.52-4.35 Omega sq(-1)，良好的归一化电化学阻抗为3.78-6.04 Omega cm(2)，550 nm处的光学透过率为61.3-80.5%，延伸性为40%。用这种方法制备的微电极阵列(MEA)在所有通道上都表现出均匀的电化学性能。在小鼠身上的研究表明，在有/没有共定位光基因起搏的情况下，原始和拉伸的银NW微电极都可以实现对心脏活动的高保真电生理监测。总而言之，这些结果为开发可伸展和透明的金属纳米线网络铺平了道路，这些网络用于高分辨率光电生物接口，与机械活动的器官，如心脏。
Recently developed optically transparent microelectrode technology provides a promising approach for simultaneous high-resolution electrical and optical biointerfacing with tissues in vivo and in vitro. A critically unmet need is designing high-performance stretchable platforms for conformal biointerfacing with mechanically active organs. Here, we report silver nanowire (Ag NW) stretchable transparent microelectrodes and interconnects that exhibit excellent electrical and electrochemical performance, high optical transparency, superior mechanical robustness and durability by a simple selective-patterning process. The fabrication method allows the direct integration of Ag NW networks on elastomeric substrates. The resulting Ag NW interface exhibits a low sheet resistance (R-sh) of 1.52-4.35 Omega sq(-1), an advantageous normalized electrochemical impedance of 3.78-6.04 Omega cm(2), a high optical transparency of 61.3-80.5% at 550 nm and a stretchability of 40%. The microelectrode arrays (MEAs) fabricated with this approach exhibit uniform electrochemical performance across all channels. Studies on mice demonstrate that both pristine and stretched Ag NW microelectrodes can achieve high-fidelity electrophysiological monitoring of cardiac activity with/without co-localized optogenetic pacing. Together, these results pave the way for developing stretchable and transparent metal nanowire networks for high-resolution opto-electric biointerfacing with mechanically active organs, such as the heart.