Characterization of pancreatic-type tissue in the liver of rat induced by polychlorinated biphenyls.
Characterization of pancreatic-type tissue in the liver of rat induced by polychlorinated biphenyls.
复制标题
多氯联苯诱导的大鼠肝脏胰腺型组织的表征。
DOI：
10.1177/34.2.2418098
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
J. K. Reddy
中科院分区：
文献类型：
--
作者：
M S Rao;M. Bendayan;R D Kimbrough;J. K. Reddy
胰腺型组织的特点是在用多氯联苯处理的大鼠肝脏中诱导透射电子显微镜和高分辨率免疫细胞化学。胰腺型组织细胞排列呈腺泡状，细胞呈小团状。通过电子显微镜下的胰腺型组织表现出非常相似的功能，正常胰腺腺泡组织，如发达的粗面内质网（RER），大量的成熟酶原颗粒，和一个位于基底部的核。蛋白A胶体金免疫细胞化学技术显示淀粉酶和胰蛋白酶原位于酶原颗粒和粗面内质网上。这些发现证实了肝脏中的该组织在形态和功能上与胰腺腺泡组织相同。
Pancreatic-type tissue induced in the livers of rats treated with polychlorinated biphenyls was characterized by transmission electron microscopy and high-resolution immunocytochemistry. The cells of pancreatic-type tissue were arranged as acini and in small groups. By electron microscopy the pancreatic-type tissue showed features very similar to normal pancreatic acinar tissue, such as well developed rough endoplasmic reticulum (RER), large numbers of mature zymogen granules, and a basally located nucleus. Protein A-gold imunocytochemical technique showed localization of amylase and trypsinogen over the zymogen granules and RER. These findings confirm that this tissue in the liver is morphologically and functionally identical to pancreatic acinar tissue.