Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement.
Surgery and stress promote cancer metastasis: new outlooks on perioperative mediating mechanisms and immune involvement.
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DOI：
10.1016/j.bbi.2012.03.006
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发表时间：
2013-03
影响因子：
15.1
通讯作者：
Ben-Eliyahu, Shamgar
中科院分区：
文献类型：
--
作者：
Neeman, Elad;Ben-Eliyahu, Shamgar
关键词：
切除原发性肿瘤的手术提供了根除癌症或阻止其进展的机会，但也被认为会促进预先存在的微转移的爆发和新转移的开始。手术的这些有害影响是通过各种机制介导的，包括手术引起的心理和生理神经内分泌和旁分泌应激反应。在这篇综述中，我们（i）描述了围手术期出现的许多风险因素，协同作用使这一短时间内对确定长期癌症复发至关重要，（ii）提出了新鉴定的有效免疫细胞群，可以破坏传统上被认为是免疫抗性的自体肿瘤细胞，从而增强了对癌症转移的免疫监视的概念，（iii）描述支持抗癌免疫作用的癌症患者体内证据，（iv）指出压力和手术诱导的癌症进展促进的神经内分泌和旁分泌介导机制，重点关注儿茶酚胺和三尖杉酯碱通过其对抗癌免疫的影响以及通过对恶性组织及其周围的直接作用的突出作用，（v）讨论不同麻醉方法和其他术中操作对免疫和癌症进展的影响，以及（vi）针对手术的免疫抑制和癌症促进作用提出预防措施。
Surgery for the removal of a primary tumor presents an opportunity to eradicate cancer or arrest its progression, but is also believed to promote the outbreak of pre-existing micrometastases and the initiation of new metastases. These deleterious effects of surgery are mediated through various mechanisms, including psychological and physiological neuroendocrine and paracrine stress responses elicited by surgery. In this review we (i) describe the many risk factors that arise during the perioperative period, acting synergistically to make this short timeframe critical for determining long-term cancer recurrence, (ii) present newly identified potent immunocyte populations that can destroy autologous tumor cells that were traditionally considered immune-resistant, thus invigorating the notion of immune-surveillance against cancer metastasis, (iii) describe in vivo evidence in cancer patients that support a role for anti-cancer immunity, (iv) indicate neuroendocrine and paracrine mediating mechanisms of stress- and surgery-induced promotion of cancer progression, focusing on the prominent role of catecholamines and prostaglandins through their impact on anti-cancer immunity, and through direct effects on the malignant tissue and its surrounding, (v) discuss the impact of different anesthetic approaches and other intra-operative procedures on immunity and cancer progression, and (vi) suggest prophylactic measures against the immunosuppressive and cancer promoting effects of surgery.
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影响因子：
8.8
作者：
Demicheli, R;Valagussa, P;Bonadonna, G
通讯作者：
Bonadonna, G
影响因子：
2.4
作者：
Ben-Eliyahu, S;Shakhar, G;Shakhar, K
通讯作者：
Shakhar, K
影响因子：
8.8
作者：
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通讯作者：
Ben-Eliyahu, S
影响因子：
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作者：
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通讯作者：
Bruene, Bernhard
影响因子：
8.8
作者：
Abramovitch, R;Marikovsky, M;Neeman, M
通讯作者：
Neeman, M