Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy
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DOI：
10.1007/s00213-013-3244-0
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Cowen, Philip J.
中科院分区：
文献类型：
--
作者：
Godlewska, Beata R.;Yip, Sarah W.;Cowen, Philip J.
谷胱甘肽（GSH）是细胞自由基的关键清除剂，双相情感障碍患者的血浆和死后脑组织中的谷胱甘肽水平可能降低。当前研究的目的是使用磁共振波谱（MRS）来测量患有双相情感障碍的年轻人的皮质谷胱甘肽水平，以确定降低的谷胱甘肽是否可能是对该疾病易感性的有用生物标志物。我们研究了13名患有DSM-IV双相情感障碍的患者和11名年龄匹配的健康对照，使用质子MRS结合SPECIAL获取技术。体素被放置在前额叶和枕叶皮层。所有患者在研究时均为临床健康且未用药。测定谷胱甘肽和其他相关神经代谢物与肌酐的关系。双相患者与对照组在前额叶或枕叶皮层的谷胱甘肽水平均无差异。同样，参与者在其他测量的皮质代谢物（包括γ -氨基丁酸、谷氨酸和n -乙酰天冬氨酸）方面与对照组没有差异。这项初步研究表明，皮质谷胱甘肽水平不太可能是在疾病早期有相对轻度情绪不稳定病史的年轻人双相情感障碍的有用特征生物标志物。降低谷胱甘肽水平可能与更严重患者的双相病理生理有关，特别是那些目前有明显情绪障碍的患者。
Rationale Glutathione (GSH) is a key scavenger for cellular free radicals, and patients with bipolar disorder may have lowered GSH levels in plasma and in post-mortem brain tissue.The objective of the current study was to use magnetic resonance spectroscopy (MRS) to measure cortical GSH levels in young people with bipolar disorder to determine if lowered GSH might be a useful biomarker of vulnerability to the illness.We studied 13 patients with DSM-IV bipolar disorder and 11 healthy age-matched controls using proton MRS in conjunction with the SPECIAL acquisition technique. Voxels were placed in prefrontal and occipital cortex. All patients were clinically euthymic at the time of study and unmedicated. GSH and other relevant neurometabolites were measured relative to creatinine.There was no difference in GSH levels between bipolar participants and controls in either prefrontal or occipital cortex. Similarly, participants showed no difference from controls in other measured cortical metabolites including gamma-aminobutyric acid, glutamate and N-acetylaspartate.This pilot study suggests that levels of cortical GSH are unlikely to be a useful trait biomarker of bipolar disorder in young people with a history of relatively mild mood instability at an early stage of illness. Lowered GSH levels may be relevant to bipolar pathophysiology in more severely ill patients, particular those with significant current mood disturbance.