Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells
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DOI：
10.1182/blood-2004-02-0646
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发表时间：
2004-10-15
期刊：
影响因子：
20.3
通讯作者：
Rooney, CM
中科院分区：
文献类型：
--
作者：
Leen, AM;Sili, U;Rooney, CM
腺病毒常在免疫功能低下的个体中引起致命感染。免疫T细胞的过继转移提供了一种治疗选择，但由于缺乏细胞免疫分子靶点的信息，以及51种人类腺病毒的免疫异质性，这种策略受到阻碍，这些腺病毒根据基因组大小、组成、同源性和组织从a到F分组。对血清阳性个体的腺病毒特异性细胞毒性T淋巴细胞（CTL）反应进行克隆分析，鉴定出5个新的CD8(+) T细胞表位，均位于衣壳蛋白六邻体的保守区域。反应性T细胞在2 - 4组之间交叉反应，而未检测到单个亚组特异性T细胞。因此，通过利用这些肽靶点，有可能制备出能够与大多数引起免疫功能低下患者疾病的腺病毒发生反应的t细胞群。(C) 2004年由美国血液病学会出版。
Adenoviruses often cause lethal infections in immunocompromised individuals. Adoptive transfer of immune T cells offers a therapeutic option, but this strategy has been hindered by the paucity of information on molecular targets of cellular immunity and by the immunologic heterogeneity of the 51 human adenoviruses, which are grouped from A to F on the basis of genome size, composition, homology, and organization. Clonal analysis of the adenovirus-specific cytotoxic T lymphocyte (CTL) responses of seropositive individuals identified 5 novel CD8(+) T-cell epitopes, all located in conserved regions of the capsid protein hexon. Reactive T cells were cross-reactive between 2 to 4 groups, while no T cells specific for a single subgroup were detected. Thus, by exploiting these peptide targets, it is possible to prepare a T-cell population capable of reacting with most adenoviruses that cause disease in immunocompromised patients. (C) 2004 by The American Society of Hematology.