Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells
Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells
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DOI：
10.4049/jimmunol.0900311
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发表时间：
2009-11-15
影响因子：
4.4
通讯作者：
Mebius, Reina E.
中科院分区：
文献类型：
--
作者：
Molenaar, Rosalie;Greuter, Mascha;Mebius, Reina E.
T细胞被印记以在组织引流淋巴结中激活时表达组织特异性归巢受体，导致它们迁移到Ag进入位点。肠道归巢分子α（4）β（7）和CCR 9的表达由视黄酸诱导，视黄酸是由视网膜脱落酶产生的维生素A代谢物，其特异性表达于树突状细胞以及粘膜引流淋巴结中的基质细胞。在这项研究中，我们证明，肠系膜淋巴结基质细胞衍生的视黄酸可以直接诱导肠道归巢分子增殖T细胞的表达，骨髓来源的树突状细胞在体外强烈增强的过程。因此，固着淋巴结基质细胞与移动的树突状细胞的合作保证了组织特异性归巢受体在活化的T细胞上的印记。免疫学杂志，2009，183：6395-6402.
T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7), and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells. The Journal of Immunology, 2009, 183: 6395-6402.