Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide
Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide
复制标题
DOI：
10.2174/0929867321666140706142930
复制
发表时间：
2014-01-01
影响因子：
4.1
通讯作者：
Wang, Rui
中科院分区：
文献类型：
--
作者：
Altaany, Zaid;Moccia, Francesco;Wang, Rui
内皮是排列在血管内表面的细胞单层，并通过控制血小板聚集、血管张力、血液流动性和纤维蛋白溶解、炎性细胞的粘附和迁移以及血管生成在维持心血管稳态中发挥核心作用。内皮功能障碍与各种心血管疾病相关，包括动脉粥样硬化、高血压、心肌梗死和糖尿病的心血管并发症。许多研究已经确定了硫化氢（H2S）对血管内皮的抗炎、抗凋亡和抗氧化作用，硫化氢是沿着一氧化氮和一氧化碳加入气体递质家族的最新成员。此外，H2S除了其众所周知的松弛血管平滑肌细胞（VSMC）的能力之外，还可以促使内皮细胞（EC）朝向血管生成并有助于伤口愈合，从而降低血压。H_2S可抑制VSMC增殖和血小板聚集。因此，H2S稳态的缺陷参与动脉粥样硬化和高血压性内皮损伤的发病机制。因此，应用硫化氢释放药物或基因治疗提高内源性硫化氢水平，可能有助于恢复内皮功能，对抗心血管疾病的进展。本文综述了近年来H2S在生理和病理条件下对内皮细胞稳态的作用及其可能的治疗应用。
The endothelium is a cellular monolayer that lines the inner surface of blood vessels and plays a central role in the maintenance of cardiovascular homeostasis by controlling platelet aggregation, vascular tone, blood fluidity and fibrinolysis, adhesion and transmigration of inflammatory cells, and angiogenesis. Endothelial dysfunctions are associated with various cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and cardiovascular complications of diabetes. Numerous studies have established the anti-inflammatory, anti-apoptotic, and anti-oxidant effects of hydrogen sulfide (H2S), the latest member to join the gasotransmitter family along with nitric oxide and carbon monoxide, on vascular endothelium. In addition, H2S may prime endothelial cells (ECs) toward angiogenesis and contribute to wound healing, besides to its well-known ability to relax vascular smooth muscle cells (VSMCs), and thereby reducing blood pressure. Finally, H2S may inhibit VSMC proliferation and platelet aggregation. Consistently, a deficit in H2S homeostasis is involved in the pathogenesis of atherosclerosis and of hyperglycaemic endothelial injury. Therefore, the application of H2S-releasing drugs or using gene therapy to increase endogenous H2S level may help restore endothelial function and antagonize the progression of cardiovascular diseases. The present article reviews recent studies on the role of H2S in endothelial homeostasis, under both physiological and pathological conditions, and its putative therapeutic applications.