Design of Experiment for Bioassay

Design of Experiment for Bioassay
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生物测定实验设计

DOI:
10.1080/01621459.1972.10481253
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发表时间:
1972
影响因子:
3.7
通讯作者:
R. Tsutakawa
R. Tsutakawa
中科院分区:
数学1区
文献类型:
--
作者:
R. Tsutakawa

文献摘要

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摘要用单参数逻辑斯谛分布来说明某些数值近似,以便找到产生小的后验方差的一阶段和两阶段生物测定设计。本文讨论了两个先验分布的使用,一个用于设计,另一个用于推理。当先验分布为正态分布时,给出了设计实验的图形。这些图表说明了在先验分布的方差较大时使用额外剂量水平的重要性。
Abstract The one-parameter logistic distribution is used to illustrate certain numerical approximations for finding one- and two-stage bioassay designs which produce small posterior variances. The article discusses the use of two prior distributions, one for design and another for inference. Graphs are given for designing experiments when the prior distributions are normal. These graphs illustrate the importance of using additional dose levels when the variance of the prior distribution is large.