EXCITATORY AMINO-ACID RECEPTOR ANTAGONIST KYNURENIC ACID ATTENUATES REWARDING POTENTIAL OF MORPHINE
EXCITATORY AMINO-ACID RECEPTOR ANTAGONIST KYNURENIC ACID ATTENUATES REWARDING POTENTIAL OF MORPHINE
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DOI：
10.1016/0014-2999(94)00462-5
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发表时间：
1994-11-03
影响因子：
5
通讯作者：
ZVARTAU, E
中科院分区：
文献类型：
--
作者：
BESPALOV, A;DUMPIS, M;ZVARTAU, E
在大鼠中研究了兴奋性氨基酸受体犬尿酸的非选择性拮抗剂（50、100 和 150 mg/kg，腹腔注射）对吗啡衍生奖赏的影响。在条件调节前注射时，犬尿酸剂量依赖性地阻断吗啡条件位置偏好的获得。先前建立的条件行为的表达也被测试前用犬尿酸预处理（剂量不降低自发运动活动）所阻断。在对照实验中，我们未能发现犬尿酸单独发挥积极的位置偏好调节或厌恶作用。犬尿酸还减弱了颅内自刺激试验中吗啡诱导的反应促进，导致反应率降低和阈值电流强度增加。在犬尿酸本身不影响自我刺激测试中的反应的剂量下观察到了这种效应。
The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats. Kynurenic acid dose dependently blocked the acquisition of morphine conditioned place preference when injected before conditioning. The expression of the previously established conditioned behavior was also blocked by the pretreatment with kynurenic acid (at the doses which do not reduce spontaneous locomotor activity) before testing. In the control experiments we failed to find that kynurenic acid alone exerts positive place preference conditioning or aversion. Kynurenic acid also attenuated the morphine-induced facilitation of responding in the intracranial self-stimulation test, causing a decrease in response rate and an increase in threshold current intensity. This effect was observed with doses at which kynurenic acid does not affect responding in the self-stimulation test by itself.