PROTEIN-TYROSINE KINASE PYK2 INVOLVED IN CA2+-INDUCED REGULATION OF ION-CHANNEL AND MAP KINASE FUNCTIONS
PROTEIN-TYROSINE KINASE PYK2 INVOLVED IN CA2+-INDUCED REGULATION OF ION-CHANNEL AND MAP KINASE FUNCTIONS
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DOI：
10.1038/376737a0
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发表时间：
1995-08-31
期刊：
影响因子：
64.8
通讯作者：
SCHLESSINGER, J
中科院分区：
文献类型：
--
作者：
LEV, S;MORENO, H;SCHLESSINGER, J
在中枢神经系统中高度表达的蛋白酪氨酸激酶PYK2响应于升高细胞内钙浓度的各种刺激以及通过蛋白激酶C活化而在酪氨酸残基上迅速磷酸化。PYK2的活化导致离子通道功能的调节和MAP激酶信号传导途径的活化。PYK2激活可能为神经系统中的各种短期和长期钙依赖性信号传导事件提供机制。
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.