MR-Based Visualization and Quantification of Three-Dimensional Flow Characteristics in the Portal Venous System
MR-Based Visualization and Quantification of Three-Dimensional Flow Characteristics in the Portal Venous System
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DOI：
10.1002/jmri.22248
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发表时间：
2010-08-01
影响因子：
4.4
通讯作者：
Markl, Michael
中科院分区：
文献类型：
--
作者：
Stankovic, Zoran;Frydrychowicz, Alex;Markl, Michael
目的：评估时间分辨血流敏感 MRI 对正常和病理性门静脉 (PV) 血流动力学进行三维 (3D) 可视化和定量的可行性。 材料和方法：对 18 名健康志愿者和 5 名肝硬化患者的门静脉血流动力学进行了评估。 ECG 和自适应呼吸导航门控流敏 4D MRI（具有三向速度编码的时间分辨 3D MRI）在 3 Tesla MR 系统（TRIO.西门子，德国）上进行。使用 3D 流线和时间分辨粒子轨迹实现定性流动分析，这些轨迹源自精确放置在光伏系统中解剖标志处的七个发射器平面。定量分析包括回顾性提取区域峰值和平均速度以及血管面积。将结果与标准 2D 血流敏感 MRI 和参考标准多普勒超声进行比较。结果：定性血流分析成功应用于整个 PV 系统。 18 名志愿者中的 17 名和 5 名患者中的 3 名的所有主要分支的静脉血流动力学均得到可靠描述，观察者间一致性良好（kappa = 0.62）。定量分析显示，3D MR 和 2D MRI (r = 0.46) 以及多普勒超声 (US) (r = 0.35) 之间的峰值速度以及 3D 和 2D MRI 之间的平均速度 (r = 0.41) 之间没有显着差异，并且具有中等一致性。与 US 相比，3D 和 2D MRI 中的 PV 面积显着更高（P < 0.01）。结论：我们成功地将 3D MR 速度映射应用于 PV 系统，提供了正常和病理血流动力学的详细定性和定量分析。
Purpose: To evaluate the feasibility of time-resolved flow-sensitive MRI for the three-dimensional (3D) visualization and quantification of normal and pathological portal venous (PV) hemodynamics.Materials and Methods: Portal venous hemodynamics were evaluated in 18 healthy volunteers and 5 patients with liver cirrhosis. ECG- and adaptive respiratory navigator gated flow-sensitive 4D MRI (time-resolved 3D MRI with three-directional velocity encoding) was performed on a 3 Tesla MR system (TRIO. Siemens, Germany). Qualitative flow analysis was achieved using 3D streamlines and time-resolved particle traces originating from seven emitter planes precisely placed at anatomical landmarks in the PV system. Quantitative analysis included retrospective extraction of regional peak and mean velocities and vessel area. Results were compared with standard 2D flow-sensitive MRI and to the reference standard Doppler ultrasound.Results: Qualitative flow analysis was successfully used in the entire PV system. Venous hemodynamics in all major branches in 17 of 18 volunteers and 3 of 5 patients were reliably depicted with good interobserver agreement (kappa = 0.62). Quantitative analysis revealed no significant differences and moderate agreement for peak velocities between 3D MR and 2D MRI (r = 0.46) and Doppler ultrasound (US) (r = 0.35) and for mean velocities between 3D and 2D MRI (r = 0.41). The PV area was significantly (P < 0.01) higher in 3D and 2D MRI compared with US.Conclusion: We successfully applied 3D MR velocity mapping in the PV system, providing a detailed qualitative and quantitative analysis of normal and pathological hemodynamics.