Central amygdalar and dorsal striatal NMDA receptor involvement in instrumental learning and spontaneous behavior
Central amygdalar and dorsal striatal NMDA receptor involvement in instrumental learning and spontaneous behavior
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DOI：
10.1037/0735-7044.118.4.715
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发表时间：
2004-08-01
影响因子：
1.9
通讯作者：
Kelley, AE
中科院分区：
文献类型：
--
作者：
Andrzejewski, ME;Sadeghian, K;Kelley, AE
皮质纹状体回路中的谷氨酸编码信号已被证明在各种形式的学习和记忆中是重要的。在本研究中，作者发现，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂的中央核杏仁核（CeA）和后外侧纹状体（PLS）受损的工具性条件反射，但在前背侧纹状体没有影响。NMDA受体拮抗作用的CeA和PLS也影响自发运动行为和某些方面的喂养。本研究结果扩展了动态神经生理过程的知识。在一个复杂的神经网络中实例化，这是哺乳动物大脑中工具性学习所必需的。
Glutamate-coded signaling in corticostriatal circuits has been shown to be important in various forms of learning and memory. In the present study, the authors found that N-methyl-D-aspartate (NMDA) receptor antagonism in the central nucleus of the amygdala (CeA) and the posterior lateral striatum (PLS) impaired instrumental conditioning but had no effect in the anterior dorsal striatum. NMDA receptor antagonism in the CeA and PLS also affected spontaneous motor behavior and certain aspects of feeding. The present findings extend knowledge of the dynamic neurophysiological processes. instantiated in a complex neural network, required for instrumental learning in the mammalian brain.