Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
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Gankyrin 通过 Nrf2 的反馈调节在肝细胞癌中发挥抗氧化作用
DOI：
10.1084/jem.20151208
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发表时间：
2016-05-02
期刊：
影响因子：
--
通讯作者：
Wang HY
中科院分区：
文献类型：
--
作者：
Yang C;Tan YX;Yang GZ;Zhang J;Pan YF;Liu C;Fu J;Chen Y;Ding ZW;Dong LW;Wang HY
Yang et al. identify a feedback loop between gankyrin, an oncoprotein overexpressed in human hepatocellular carcinoma (HCC), and Nrf2. The positive feedback modulates a series of antioxidant enzymes that lower intracellular reactive oxygen species to confer protection from mitochondrial damage and cell death.
