Long-term prediction of prostate cancer up to 25 years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50 years
Long-term prediction of prostate cancer up to 25 years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50 years
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DOI：
10.1200/jco.2006.06.9351
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发表时间：
2007-02-01
影响因子：
45.3
通讯作者：
Berglund, Goran
中科院分区：
文献类型：
--
作者：
Lilja, Hans;Ulmert, David;Berglund, Goran
目的我们检测了前列腺特异性抗原（PSA）的形成和人激肽释放酶2（hK 2）在44 - 50岁时的测定是否可预测前列腺癌的长期发病风险。方法从1974年到1986年，21,277名年龄≥ 20岁的男性在静脉穿刺后，结论在44 ~ 50岁时进行一次PSA检测可预测随后临床诊断的前列腺疾病癌这增加了前列腺癌筛查项目风险分层的可能性。
Purpose We examined whether prostate-specific antigen (PSA) forms and human kallikrein 2 (hK2) measured at age 44 to 50 years predict long-term risk of incident prostate cancer.Methods From 1974 to 1986, 21,277 men age = 20 years after venipuncture, and the predictive value remained unchanged in an analysis restricted to palpable disease.Conclusion A single PSA test at age 44 to 50 years predicts subsequent clinically diagnosed prostate cancer. This raises the possibility of risk stratification for prostate cancer screening programs.