Established prostate cancer susceptibility variants are not associated with disease outcome.
Established prostate cancer susceptibility variants are not associated with disease outcome.
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DOI：
10.1158/1055-9965.epi-08-1148
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Xu J
中科院分区：
文献类型：
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作者：
Wiklund FE;Adami HO;Zheng SL;Stattin P;Isaacs WB;Grönberg H;Xu J
最近的全基因组关联研究已经成功地确定了与前列腺癌风险相关的常见序列变异;然而，它们在前列腺癌预后中的重要性仍然未知。为了评估经证实的前列腺癌易感性变异与前列腺癌预后，我们在2001年至2003年期间确定的2，875例瑞典前列腺癌病例队列中对16种已确定的易感性变异进行了基因分型，并对生命状态进行了完整的随访，直至2008年1月。考克斯回归模型，调整年龄，临床分期，病理分级，淋巴结或远处转移，和诊断血清前列腺特异性抗原水平，用于评估风险变异和前列腺癌特异性生存之间的关联。在随访期间，626名男性死亡，其中440人患有前列腺癌，这被列为他们死亡的根本原因。我们发现，无论是在探索个体变异还是在评估所有变异的累积效应时，任何探索的序列变异与前列腺癌特异性死亡率之间都没有关联。我们的结论是，迄今为止建立的前列腺癌易感性变异与前列腺癌的致死潜力无关。
Recent genome-wide association studies have been successful in identifying common sequence variants associated with prostate cancer risk; however, their importance in prostate cancer prognosis remains unknown. To assess confirmed prostate cancer susceptibility variants with prostate cancer prognosis, we genotyped 16 established susceptibility variants in a Swedish cohort of 2,875 prostate cancer cases, ascertained between 2001 and 2003, with complete follow-up regarding vital status through January 2008. Cox regression models, adjusted for age, clinical stage, pathologic grade, nodal or distant metastases, and diagnostic serum levels of prostate-specific antigen level, were used to assess association between risk variants and prostate cancer–specific survival. During follow-up, 626 men died, and of those, 440 had prostate cancer classified as their underlying cause of death. We found no association between any of the explored sequence variants and prostate cancer–specific mortality, either in exploring individual variants or in assessing the cumulative effect of all variants. We conclude that hitherto established prostate cancer susceptibility variants are not associated with the lethal potential of prostate cancer.