RIFT-VALLEY FEVER AMONG DOMESTIC-ANIMALS IN THE RECENT WEST-AFRICAN OUTBREAK
RIFT-VALLEY FEVER AMONG DOMESTIC-ANIMALS IN THE RECENT WEST-AFRICAN OUTBREAK
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DOI：
10.1016/s0923-2516(89)80086-x
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
TOURAY, EM
中科院分区：
文献类型：
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作者：
KSIAZEK, TG;JOUAN, A;TOURAY, EM
塞内加尔河流域人群中的严重出血性疾病使 1987 年爆发的裂谷热病毒 (RVFV) 引起了科学界的关注。与之前的裂谷热病毒爆发一样，当地牧民报告牲畜流产和疾病发生率很高。血清样本取自罗索附近地区（人类感染研究最充分的地区）以及远离已知人类疾病的其他地区的家畜群体。在人类疾病高发地区的动物中，抗体流行率高达 85%，大约 80% 的血清对 RVFV IgG 和病毒特异性 IgM 抗体均呈阳性。相比之下，同一地区的人群 RVFV 抗体患病率较低，为 40% 或更低，其中 90% 的人也呈 IgM 阳性。疫区以南280公里沿海地区牲畜血清RVFV抗体呈阴性。因此，RVFV 特异性 IgG 和 IgM 抗体的检测提供了近期疾病活动的证据，无需在人群或个体中确定病前抗体水平，也无需进行病毒分离。随后，在塞内加尔河洪泛平原以南 130 公里的费洛地区检测到中等水平的 IgG 和 IgM，证实流域的另一个地区也发生了裂谷热病毒传播。对罗索以南 340 公里的冈比亚家养有蹄类动物进行的类似血清学检测表明，抗体流行率与近期 RVFV 传播的较低水平一致，即 24% IgG 阳性，其中 6% 的阳性血清还含有 RVFV 特异性 IgM。
Severe haemorrhagic disease among the human populations of the Senegal River Basin brought the Rift Valley fever virus (RVFV) outbreak of 1987 to the attention of science. As in previous RVFV outbreaks, local herdsmen reported a high incidence of abortion and disease in their livestock. Serum samples were obtained from domestic animal populations from areas near Rosso, the best studied focus of human infection, as well as other areas distant from known human disease. Among animals from the area of high incidence of human disease, antibody prevalence was as high as 85%, with approximately 80% of the sera positive for both RVFV IgG- and viral-specific IgM antibodies. In contrast, human populations in the same area had lower RVFV antibody prevalences, 40% or less, with 90% also being IgM-positive. Sera from livestock in coastal areas 280 km south of the epidemic area were negative for RVFV antibodies. Thus, the detection of RVFV specific IgG and IgM antibodies provided evidence of recent disease activity without the requirement to establish pre-disease antibody levels in populations or individuals and without viral isolation. Subsequently, detection of modest levels of IgG and IgM in the Ferlo region, 130 km south of the Senegal River flood plain, established that RVFV transmission also occurred in another area of the basin. Similar serological testing of domestic ungulates in The Gambia, 340 km south of Rosso, demonstrated antibody prevalence consistent with a lower level of recent transmission of RVFV, i.e., 24% IgG-positive with 6% of the positive sera also having RVFV-specific IgM.