The fate of human and bovine tubercle bacilli in various organs of the rabbit.
The fate of human and bovine tubercle bacilli in various organs of the rabbit.
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DOI：
10.1084/jem.48.2.155
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发表时间：
1928-08-01
影响因子：
15.3
通讯作者：
Lurie, MB
中科院分区：
文献类型：
--
作者：
Lurie, MB
用不同剂量的人和牛结核杆菌静脉感染家兔，观察肺、肝、脾、肾和骨髓中结核杆菌的命运，然后测定在感染过程中不同时间间隔内从鸡蛋培养基上相当数量的组织中可回收的结核杆菌菌落数。杆菌最初在各器官中的分布遵循颗粒物的分布，每克颗粒物的分布顺序如下。组织：脾、肝、肺、骨髓、肾。起初，人和牛两种类型的结核杆菌都在所有器官中生长，但两种类型的结核杆菌在不同器官中的生长速度不同。在兔子的几个器官中，人型比牛型生长得更快。人类类型的这种更快的增长之后是更早和更彻底的毁灭。对于这两种类型，破坏首先发生在肝脏，脾脏和骨髓中。在肺和肾中，人型的破坏发生在以后，牛型的不受限制的繁殖在这些器官中继续，直到动物死亡。对人体而言，剂量较小时，肝、脾和骨髓的破坏比剂量较大时晚。对于这两种类型，在给定的时间内，在大剂量后某些器官的破坏比小剂量后更完全。哺乳动物结核杆菌对家兔的毒力与其初始生长速度呈部分负相关。与生长较慢的牛型相比，人型在兔子体内生长得更快，并导致更早的身体反应和有机体的破坏。各种器官的破坏起初很快，随着时间的推移进展缓慢。一些证据表明，各种器官对结核病的后天抵抗力是其对结核杆菌的天然抵抗力的增强。
The fate of tubercle bacilli in the lung, liver, spleen, kidney and bone marrow of rabbits infected intravenously with varying doses of human and bovine tubercle bacilli was followed by determining the number of colonies of tubercle bacilli recoverable from comparable quantites of tissue on egg media at varying intervals during the course of infection. The original distribution of the bacilli to the various organs followed the distribution of particulate matter in the following order per gm. of tissue: spleen, liver, lung, bone marrow, kidney. At first the tubercle bacilli, both of human and bovine types, grow in all the organs, but the rate of growth of the 2 types differs in the various organs. The human type grows faster in the several organs of the rabbit than does the bovine type. This more rapid growth of the human type is followed by an earlier and more complete destruction. With both types, destruction occurs first in the liver, spleen and bone marrow. In the lung and kidney, destruction of the human type takes place later, and unchecked multiplication of the bovine type continues in these organs until death of the animal. With smaller doses of the human type, destruction is brought about later in the liver, spleen and bone marrow than with larger doses. With both types, in a given time, destruction is more complete in some organs after a large than after a small dose. It is suggested that the virulence of a mammalian tubercle bacillus for rabbits is partly inversely related to the rate of its initial growth. The human type grows faster in the body of the rabbit and brings about an earlier altered body reaction and destruction of the organism than does the more slowly growing bovine type. Destruction in the various organs is rapid at first and progresses more slowly as time passes. Some evidence is presented that this acquired resistance to tuberculosis in the various organs is an increment of their natural resistance to tubercle bacilli.