Heritability of Urinary Traits That Contribute to Nephrolithiasis
Heritability of Urinary Traits That Contribute to Nephrolithiasis
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DOI：
10.2215/cjn.08210813
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发表时间：
2014-05-07
影响因子：
9.8
通讯作者：
Kardia, Sharon L. R.
中科院分区：
文献类型：
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作者：
Lieske, John C.;Turner, Stephen T.;Kardia, Sharon L. R.
背景和目的肾结石及其危险因素聚集在家族中，但很少有研究系统地估计与肾结石风险相关的众多尿液性状的遗传力和遗传相关性。设计、设置、参与者和测量从明尼苏达州罗切斯特市动脉病遗传流行病学网络队列收集24小时尿样，以测量尿液过饱和的决定因素。饮食使用Viocare食物频率问卷进行评估。结果样本来自811名个体(男性344名，女性467名；平均年龄669岁)。年龄、性别和体重与大多数尿液特征显著相关。许多尿液排泄物(钙、镁、柠檬酸排泄物)有很强的遗传力证据(P
Background and objectivesKidney stones and their risk factors aggregate in families, yet few studies have systematically estimated heritabilities and genetic correlations of the numerous urinary traits associated with risk of kidney stones.Design, setting, participants, & measurementsTwenty-four-hour urine samples were collected from the Genetic Epidemiology Network of Arteriopathy cohort of families in Rochester, Minnesota, to measure urinary determinants of supersaturation. Diet was assessed using the Viocare food frequency questionnaire. Heritabilities and genetic correlations among the urinary traits were estimated using variance components methods.ResultsSamples were available from 811 individuals (344 men, 467 women; mean age 669 years). Age, sex, and weight were significantly correlated with the majority of urinary traits. Many urine excretions (calcium, magnesium, citrate excretion) had strong evidence for heritability (P