Chrysophanol improves memory ability of d-galactose and Abeta25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus.
Chrysophanol improves memory ability of d-galactose and Abeta25-35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM-CaMKIV signal pathway in hippocampus.
复制标题
大黄酚可改善 d-半乳糖和 Abeta25-35 治疗大鼠的记忆能力，这与抑制海马 tau 过度磷酸化和 CaM-CaMKIV 信号通路相关。
DOI：
10.1007/s13205-020-2103-z
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发表时间：
2020
期刊：
影响因子：
2.8
通讯作者：
Cai Biao
中科院分区：
文献类型：
--
作者：
Ye Ting;Li Xinquan;Zhou Peng;Ye Shu;Gao Huawu;Hua Rupeng;Ma Junlong;Wang Yan;Cai Biao
本研究旨在探讨大黄酚（Escherophanol，Escherophanol，Escherophanol）对阿尔茨海默病（Alzheimer's disease，AD）的影响。我们还试图了解潜在的机制。采用d-半乳糖腹腔注射联合β-淀粉样肽（25-35）脑内注射的方法建立阿尔茨海默病大鼠模型，观察了丹参对大鼠学习记忆能力、海马神经元变化、海马CA 1区超微结构及海马内CaM、CaMKK、CaMKIV、p-CaMKIV和p-tau蛋白水平的影响。结果表明，丹参能明显改善AD大鼠的认知功能障碍，减轻海马神经元的损伤，防止海马CA 1区神经元的超微结构改变，降低海马CaM、CaMKK、p-CaMKIV和p-tau蛋白水平。这些结果提示，大黄酚可能通过抑制tau蛋白的过度磷酸化和CaM-CaMKIV信号通路而改善阿尔茨海默病大鼠的记忆能力。
This study was aimed to investigate the effect of Chrysophanol (CHR) on Alzheimer’s disease. We also attempted to understand the potential mechanisms. An Alzheimer’s disease rat model was established using an intraperitoneal injection ofd-galactose combined with an intracerebral injection of amyloid-β peptide (25–35), and the effect of CHR on the learning and memory ability, the hippocampal neurons change, the ultrastructure of the hippocampal CA1 region, the protein levels of CaM, CaMKK, CaMKIV, p-CaMKIV and p-tau in the hippocampus of rats were studied. The results showed that CHR significantly improved the cognitive deficits, alleviated hippocampal neurons damage, prevented the ultrastructure alteration of neurons in hippocampal CA1 region, and reduced the protein levels of CaM, CaMKK, p-CaMKIV and p-tau in the hippocampus of AD rats. These results suggested that Chrysophanol could improve memory ability of Alzheimer’s disease rat by inhibiting tau hyperphosphorylation and the CaM–CaMKIV signal pathway.