HEAVY SMOKERS SMOKING CESSATION AND CLONIDINE RESULTS OF A DOUBLE-BLIND RANDOMIZED TRIAL
HEAVY SMOKERS SMOKING CESSATION AND CLONIDINE RESULTS OF A DOUBLE-BLIND RANDOMIZED TRIAL
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DOI：
10.1001/jama.259.19.2863
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发表时间：
1988-01-01
影响因子：
--
通讯作者：
COVEY L S
中科院分区：
文献类型：
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作者：
GLASSMAN A H;STETNER F;COVEY L S
71名戒烟失败的重度吸烟者参加了一项随机临床试验，以测试可乐定作为戒烟辅助药物的疗效。接受可乐定治疗的受试者(通过血清可替宁浓度证实)的成功率是安慰剂组的两倍以上。当数据按性别分层时，在女性中存在的强烈影响在男性中并不明显。六个月后，接受可乐定治疗的吸烟者的戒烟率仍然显著高于接受安慰剂治疗的吸烟者。数据还显示，在该样本中，严重抑郁症病史的患病率出人意料地高(61%)，而且无论接受何种治疗，这种病史都会对戒烟产生显著的负面影响。这些发现高度暗示可乐定在戒烟中的重要作用，值得进一步研究以建立长期(>。12个月)的疗效，并复制尼古丁依赖和抑郁之间的联系。
Seventy-one heavy smokers who had failed in previous attempts to stop smoking participated in a randomized clinical trial to test the efficacy of clonidine as an aid in smoking cessation. The success rate in clonidine-treated subjects (verified by serum cotinine concentration) was more than twice that in the placebo-treated subjects. When the data were stratified by gender, a strong effect present in women was not apparent in men. After six months, cessation rates remained significantly higher among smokers treated with clonidine than those receiving placebo. The data also revealed an unexpectedly high prevalence (61%) of a history of major depression in this sample and a significant negative effects of such a history on cessation regardless of treatment. These findings, highly suggestive of an important role of clonidine in smoking cessation, warrant further studies to establish the long-term (.gtoreq. 12 months) efficacy of this drug and to replicate the association between nicotine dependence and depression.