Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy.
Polymorphisms in adenosine receptor genes are associated with infarct size in patients with ischemic cardiomyopathy.
复制标题
腺苷受体基因的多态性与缺血性心肌病患者的梗塞面积相关。
DOI：
10.1038/sj.clpt.6100331
复制
发表时间：
2007
影响因子：
6.7
通讯作者：
Feldman,AM
中科院分区：
文献类型：
--
作者：
Tang,Z;Diamond,MA;Chen,J-M;Holly,TA;Bonow,RO;Dasgupta,A;Hyslop,T;Purzycki,A;Wagner,J;McNamara,DM;Kukulski,T;Wos,S;Velazquez,EJ;Ardlie,K;Feldman,AM
The goal of this experiment was to identify the presence of genetic variants in the adenosine receptor genes and assess their relationship to infarct size in a population of patients with ischemic cardiomyopathy. Adenosine receptors play an important role in protecting the heart during ischemia and in mediating the effects of ischemic preconditioning. We sequenced DNA samples from 273 individuals with ischemic cardiomyopathy and from 203 normal controls to identify the presence of genetic variants in the adenosine receptor genes. Subsequently, we analyzed the relationship between the identified genetic variants and infarct size, left ventricular size, and left ventricular function. Three variants in the 3′‐untranslated region of the A1‐adenosine gene (nt 1689 C/A, nt 2206 Tdel, nt 2683del36) and an informative polymorphism in the coding region of the A3‐adenosine gene (nt 1509 A/C I248L) were associated with changes in infarct size. These results suggest that genetic variants in the adenosine receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.Clinical Pharmacology & Therapeutics(2007)82, 435–440; doi:10.1038/sj.clpt.6100331; published online 29 August 2007
