INTERLEUKIN-1-BETA, HUMAN-LEUKOCYTE ANTIGEN HLA-DR-ALPHA, AND TRANSFORMING GROWTH-FACTOR-BETA EXPRESSION IN ENDOMETRIUM, PLACENTA, AND PLACENTAL MEMBRANES
INTERLEUKIN-1-BETA, HUMAN-LEUKOCYTE ANTIGEN HLA-DR-ALPHA, AND TRANSFORMING GROWTH-FACTOR-BETA EXPRESSION IN ENDOMETRIUM, PLACENTA, AND PLACENTAL MEMBRANES
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DOI：
10.1016/0002-9378(90)90601-3
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发表时间：
1990-11-01
影响因子：
9.8
通讯作者：
TURNER, T
中科院分区：
文献类型：
--
作者：
KAUMA, S;MATT, D;TURNER, T
母体对胎儿半同种异体移植物的免疫识别似乎对胎儿的生存和生长是必要的和有益的。白介素- 1. - beta。和人白细胞抗原HLA-DR对免疫系统识别外来抗原很重要，而转化生长因子-。抑制白细胞介素-1 - β的许多免疫刺激特性。在这项研究中，我们发现妊娠早期蜕膜和足月胎盘膜表达明显较高水平的白细胞介素-1 - β。白介素- 1. - beta。信使核糖核酸和人白细胞抗原hla - dr - α。信使核糖核酸比子宫内膜增生和分泌多。胎儿胎盘中几乎没有白细胞介素-1 - β。白介素- 1. - beta。信使核糖核酸，或人白细胞抗原hla - dr - α。信使核糖核酸表达。在母胎界面发现的所有组织，包括妊娠早期蜕膜、胎盘和胎盘膜，都含有转化生长因子- β。表达了转化生长因子。1信使核糖核酸。基于这些发现，我们建议个体白细胞介素-1 - β的增加。和人白细胞抗原hla - dr - α。妊娠期间可能参与母体对胎儿半同种异体移植物的识别，即转化生长因子- β。生产可能调节局部母体免疫反应和防止胎儿排斥。
Maternal immune recognition of the fetal semiallograft appears to be necessary and beneficial for fetal survival and growth. Interleukin-1.beta. and human leukocyte antigen HLA-DR are important for foreign antigen recognition by the immune system, whereas transforming growth factor-.beta. inhibits many of the immunostimulatory properties of interleukin-1.beta.. In this study we found that first-trimester decidua and term placental membranes expressed significantly higher levels of interleukin-1.beta., interleukin-1.beta. messenger ribonucleic acid, and human leukocyte antigen HLA-DR.alpha. messenger ribonucleic acid than proliferative and secretory endometrium. Fetal placenta had little, if any, interleukin-1.beta., interleukin-1.beta. messenger ribonucleic acid, or human leukocyte antigen HLA-DR.alpha. messenger ribonucleic acid expression. All tissues found at the maternal-fetal interface, including first-trimester decidua, placenta, and placental membranes, contained transforming growth factor-.beta. and expressed transforming growth factor-.beta.1 messenger ribonucleic acid. On the basis of these findings, we suggest that the increase in decidual interleukin-1.beta. and human leukocyte antigen HLA-DR.alpha. during pregnancy may be involved in maternal recognition of the fetal semiallograft and that transforming growth factor-.beta. production may regulate the local maternal immune response and prevent rejection of the fetus.