Effects of Sleep Deprivation on Functional Connectivity of Brain Regions after High-Intensity Exercise in Adolescents
Effects of Sleep Deprivation on Functional Connectivity of Brain Regions after High-Intensity Exercise in Adolescents
复制标题
睡眠剥夺对青少年高强度运动后大脑区域功能连接的影响
DOI：
10.3390/su142316175
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发表时间：
2022-12-01
期刊：
影响因子：
3.9
通讯作者：
Chi, Aiping
中科院分区：
文献类型：
--
作者：
Niu, Xiaodan;Chi, Puyan;Chi, Aiping
睡眠不足会导致身体中枢疲劳，进而影响大脑功能，同样，剧烈运动会导致中枢和外周疲劳。本研究旨在通过检测脑电信号来表征睡眠剥夺条件下剧烈运动后的大脑状态，特别是相关脑区的功能变化。筛选了30名健康青少年参加试验，开发了睡眠剥夺模型，并在第二天早上进行了跑步锻炼。同时，使用32导体脑电图采集系统（Neuroscan）从受试者收集运动前和运动后的脑电图（EEG）数据，并使用MATLAB（2013 b）对数据进行分析以处理数据并分析不同大脑连接的相位滞后指数（PLI）和图论度量。与对照组相比，运动前睡眠剥夺组在Delta带的中央和右侧颞叶的功能性脑连接明显降低（p < 0.05），Theta带中顶叶和枕叶区域的功能性脑连接显著降低（p < 0.05），并且在Beta2带中的左颞区和右顶叶区中的功能性脑连接显著更高（p < 0.05）。在运动后睡眠剥夺组中，Delta带的中央至右枕叶和中央区域的功能性脑连接显著降低（p < 0.05），在Theta、Alpha2和Beta1带的全脑区域中显著较高（p < 0.05和0.001），在Alpha1带的右侧中央、右侧顶叶和右侧颞叶区域显著较高在Beta2带，从左额区到右顶区的功能性脑连接显著降低（p < 0.05）。脑功能网络特性的结果显示，与对照组相比，运动前睡眠剥夺组Delta带的聚类系数显著降低（p < 0.05），Theta带的特征路径长度和整体效率显著降低（p < 0.05和0.001）。运动后睡眠剥夺组显示出显著更高的聚类系数、输入长度和局部效率（p < 0.001），Delta和Theta波段的总体效率显著降低（p < 0.001），以及显著更高的聚类系数和局部效率（p < 0.001），并且与对照组相比，α 1带的输入长度和整体效率显著降低（p < 0.001）。睡眠剥夺后，运动前的休息状态降低了青少年大脑功能网络中的信息传递速率，减缓了大脑区域之间的信息传递。在进行剧烈运动后，睡眠不足会导致青少年运动表现下降。经过长时间的高强度运动，大脑活动逐渐受到抑制，导致工作效率更低，最终增加青少年的信息传递。
Lack of sleep causes central fatigue in the body, which in turn affects brain function, and similarly, intense exercise causes both central and peripheral fatigue. This study aims to characterize the brain state, and in particular the functional changes in the relevant brain regions, after intense exercise in sleep-deprived conditions by detecting EEG signals. Thirty healthy adolescents were screened to participate in the trial, a sleep-deprivation model was developed, and a running exercise was performed the following morning. Meanwhile, pre-exercise and post-exercise Electroencephalogram (EEG) data were collected from the subjects using a 32-conductor electroencephalogram acquisition system (Neuroscan), and the data were analyzed using MATLAB (2013b) to process the data and analyzed Phase Lag Index (PLI) and graph theory metrics for different brain connections. Compared with the control group, the pre-exercise sleep-deprivation group showed significantly lower functional brain connectivity in the central and right temporal lobes in the Delta band (p < 0.05), significantly lower functional brain connectivity in the parietal and occipital regions in the Theta band (p < 0.05), and significantly higher functional brain connectivity in the left temporal and right parietal regions in the Beta2 band (p < 0.05). In the post-exercise sleep-deprivation group, functional brain connectivity was significantly lower in the central to right occipital and central regions in the Delta band (p < 0.05), significantly higher in the whole brain regions in the Theta, Alpha2, and Beta1 bands (p < 0.05 and 0.001), significantly higher in the right central, right parietal, and right temporal regions in the Alpha1 band (p < 0.05), and in the Beta2 band, the functional brain connections from the left frontal region to the right parietal region were significantly lower (p < 0.05). The results of the brain functional network properties showed that the clustering coefficients in the Delta band were significantly lower in the pre-exercise sleep-deprivation group compared to the control group (p < 0.05); the characteristic path length and global efficiency in the Theta band were significantly lower (p < 0.05 and 0.001). The post-exercise sleep-deprivation group showed significantly higher clustering coefficients, input lengths, and local efficiencies (p < 0.001), and significantly lower global efficiencies in the Delta and Theta bands (p < 0.001), and significantly higher clustering coefficients and local efficiencies (p < 0.001) and significantly lower input lengths and global efficiencies in the Alpha1 band compared with the control group (p < 0.001). After sleep deprivation, the pre-exercise resting state reduces the rate of information transfer in the functional networks of the adolescent brain, slowing the transfer of information between brain regions. After performing strenuous exercise, sleep deprivation leads to decreased athletic performance in adolescents. After a prolonged period of intense exercise, brain activity is gradually suppressed, resulting in even slower work efficiency and, eventually, increased information transfer in adolescents.