Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium.
Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium.
复制标题
叶酸摄入量以及口腔和咽癌的风险：国际头颈癌流行病学联盟内的合并分析。
DOI：
10.1002/ijc.29044
复制
发表时间：
2015-02-15
影响因子：
6.4
通讯作者：
Boccia, Stefania
中科院分区：
文献类型：
--
作者：
Galeone, Carlotta;Edefonti, Valeria;Parpinel, Maria;Leoncini, Emanuele;Matsuo, Keitaro;Talamini, Renato;Olshan, Andrew F;Zevallos, Jose P;Winn, Deborah M;Jayaprakash, Vijayvel;Moysich, Kirsten;Zhang, Zuo-Feng;Morgenstern, Hal;Levi, Fabio;Bosetti, Cristina;Kelsey, Karl;McClean, Michael;Schantz, Stimson;Yu, Guo-Pei;Boffetta, Paolo;Lee, Yuan-Chin Amy;Hashibe, Mia;La Vecchia, Carlo;Boccia, Stefania
有研究表明，叶酸摄入量和血清叶酸水平与患口腔和咽癌(OPC)的风险呈负相关，但大多数研究都受到样本量的限制，很少有关于膳食叶酸来源的报道。这项研究的目的是在国际头颈部癌症流行病学(INHANCE)联盟内调查叶酸摄入与OPC风险之间的关系。我们分析了参加INHANCE联盟的10个病例对照研究的个人水平数据，包括5,127个病例和13,249个对照。估计了总叶酸摄入量(天然、强化和补充)和仅天然叶酸与OPC风险之间的优势比(OR)和相应的95%可信区间(CI)。我们发现总叶酸摄入量与总的OPC风险呈负相关(最高和最低五分之一的调整OR为0.65，95%CI：0.43-0.99)，与口腔的相关性更强(OR=0.57，95%CI：0.43-0.75)。仅从自然来源摄取叶酸也观察到类似的反向关联，尽管略弱(OR=0.64，95%CI：0.45-0.91)。与从不饮酒或不饮酒的叶酸摄入量高的人群相比，叶酸摄入量低的重度饮酒者发生OPC的风险最高(OR=4.05，95%CI：3.43~4.79)；交互作用所致的OPC归因比例为11.1%(95%CI：1.4~20.8%)。本项目的大量病例对照研究支持总叶酸摄入量对OPC风险的保护作用。
There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPC), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. This study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from 10 case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest versus the lowest quintile was 0.65, 95% CI: 0.43–0.99), with a stronger association for oral cavity (OR=0.57, 95% CI: 0.43–0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only (OR=0.64, 95% CI: 0.45–0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR=4.05, 95% CI: 3.43–4.79); the attributable proportion due to interaction was 11.1%(95% CI: 1.4–20.8%). The present project of a large pool of case-control studies supports a protective effect total folate intake on OPC risk.