High Thyroid-Stimulating Hormone Level is Associated with the Risk of Developing Atherosclerosis in Subclinical Hypothyroidism
High Thyroid-Stimulating Hormone Level is Associated with the Risk of Developing Atherosclerosis in Subclinical Hypothyroidism
复制标题
高促甲状腺激素水平与亚临床甲状腺功能减退症发生动脉粥样硬化的风险相关
DOI：
10.1055/s-0034-1394370
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发表时间：
2015-03-01
影响因子：
2.2
通讯作者：
Tian, L. M.
中科院分区：
文献类型：
--
作者：
Gao, C. X.;Yang, B.;Tian, L. M.
本研究的目的是评估促甲状腺激素（TSH）在亚临床甲状腺功能减退（SCH）患者发生动脉粥样硬化风险中的潜在作用。本研究招募了240例SCH患者和150例甲状腺功能正常志愿者。SCH患者根据TSH水平分为2组（A组：TSH < 10 mIU/l; B组：TSH > 10 mIU/l）。对所有受试者进行临床和生化参数检查。内脂素、网膜素-1和循环内皮生物标志物被测量。B组患者接受左旋甲状腺素替代治疗以达到甲状腺功能正常;甲状腺功能正常6个月后重复所有测量。与甲状腺功能正常的受试者相比，SCH患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和C反应蛋白（CRP）水平较高，一氧化氮（NO）和网膜素-1水平较低（均p < 0.05）。L-甲状腺素替代治疗后，TC、LDL-C和CRP水平显著降低，而NO和网膜素-1水平显著升高。多元线性逐步回归分析显示，网膜素-1与BMI、TSH独立相关; NO与年龄、TSH、LDL-C、网膜素-1独立相关。高TSH水平有助于SCH的内皮功能障碍，而TSH诱导的网膜素-1减少提供了SCH和动脉粥样硬化风险之间的新联系。
he aim of our study was to assess the potential role of thyroid-stimulating hormone (TSH) in the risk of developing atherosclerosis in subclinical hypothyroidism (SCH). A cohort of 240 SCH patients and 150 euthyroid volunteers were recruited for the study. SCH patients were stratified into 2 groups according to TSH levels (group A: TSH < 10 mIU/l; group B: TSH > 10 mIU/l). All subjects were examined for clinical and biochemical parameters. Visfatin, omentin-1, and circulating endothelial biomarkers were measured. Patients in group B received l-thyroxine replacement to achieve euthyroidism; after 6 months of euthyroidism all measurements were repeated. Patients with SCH had higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) levels and lower nitric oxide (NO) and omentin-1 levels compared to euthyroid subjects (all p < 0.05). TC, LDL-C, and CRP decreased significantly, while NO and omentin-1 levels increased significantly after l-thyroxine replacement. Based on multivariate liner stepwise regression analysis, omentin-1 was independently correlated with BMI and TSH; NO was independently correlated with age, TSH, LDL-C, and omentin-1. High TSH level contributes to endothelial dysfunction in SCH, while TSH-induced decrease of omentin-1 provides a new link between SCH and atherogenic risk.